On a coupled sde-PDE system modeling ACID-mediated tumor invasion

Sandesh Athni Hiremath, Christina Surulescu, A. Zhigun, Stefanie Sonner

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Abstract

We propose and analyze a multiscale model for acid-mediated tumor invasion accounting for stochastic effects on the subcellular level. The setting involves a PDE of reaction-diffusion-taxis type describing the evolution of the tumor cell density, the movement being directed towards pH gradients in the local microenvironment, which is coupled to a PDE-SDE system characterizing the dynamics of extracellular and intracellular proton concentrations, respectively. The global well-posedness of the model is shown and numerical simulations are performed in order to illustrate the solution behavior.
Original languageEnglish
Pages (from-to)2339-2369
Number of pages31
JournalDiscrete and Continuous Dynamical Systems - Series B
Volume23
Issue number6
DOIs
Publication statusPublished - Aug 2018

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