On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

María L. Formica, Daniel A. Real, Matías L. Picchio, Elise Catlin, Ryan F. Donnelly, Alejandro J. Paredes

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)
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Abstract

The administration of drugs to the central nervous system (CNS) is primarily controlled by the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds from the blood to the brain's extracellular fluid. Although currently available treatments for brain diseases that affect millions of people globally are partially effective, they are associated with severe side effects of systemic drug distribution. On the other hand, the ability of certain drugs to permeate through the BBB is impeded by their physicochemical properties, achieving sub-therapeutic concentrations in their target tissues. In this sense, the intranasal route with its unique anatomical features provides a promising passage for the delivery of drugs to the brain. Nanoparticle-based systems, in particular, have demonstrated an outstanding capacity to overcome the challenges presented by the intranasal route and produce drug accumulation in the brain while avoiding systemic distribution. This review covers recent developments in the use of polymer, lipid, and inorganic nanoparticles, as well as drug nanocrystals, to deliver drugs to the brain via intranasal administration. A general discussion including favourable aspects and limitations of this approach is also provided.
Original languageEnglish
Article number101631
JournalApplied Materials Today
Volume29
Early online date05 Sept 2022
DOIs
Publication statusPublished - Dec 2022

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