The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
Forsyth, S., Gunaratne, N., Hardacre, C., McKeown, A., & Rooney, D. (2006). One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent. Organic Process Research & Development, 10 (1)(1), 94-102. https://doi.org/10.1021/op050172m