One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

Stewart Forsyth; Nimal Gunaratne; Christopher Hardacre; A. McKeown; David Rooney

doi:10.1021/op050172m

One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

Stewart Forsyth, Nimal Gunaratne, Christopher Hardacre, A. McKeown, David Rooney

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.

Original language	English
Pages (from-to)	94-102
Number of pages	9
Journal	Organic Process Research & Development
Volume	10 (1)
Issue number	1
DOIs	https://doi.org/10.1021/op050172m
Publication status	Published - Nov 2006

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry

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abstract = "The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.",

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AU - Rooney, David

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AB - The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.

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One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

Abstract

ASJC Scopus subject areas

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