One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

Stewart Forsyth, Nimal Gunaratne, Christopher Hardacre, A. McKeown, David Rooney

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.
Original languageEnglish
Pages (from-to)94-102
Number of pages9
JournalOrganic Process Research & Development
Volume10 (1)
Issue number1
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

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