Abstract
Purpose: To study OCT-A findings in young patients affected with CHM Methods: Young patients affected with CHM and age-matched control subjects were consecutively enrolled at the Regional Reference Center for Hereditary Retinal Degenerations at the Eye Clinic in Florence. All patients underwent a complete ophthalmic examination including best-corrected visual acuity (BCVA), fundus autofluorescence (FA), optical coherence tomography (SS-OCT) and 3 × 3 mm swept-source OCT angiography (SS-OCTA). Superficial capillary plexus (SCP), deep capillary plexus (DCP) and OCT-A choriocapillaris slabs (CC) were processed using Imagej software to identify vessel density (VD). Results: Seven patients affected with CHM (14 eyes) and 7 age–matched control subjects (14 eyes) were included in our study. Visual acuity was 20/20 in all subjects. The detected CRT was significantly lower in the control group (212 ± 8,01 µm) in comparison with the patients (234 ± 53,7 µm), p < 0.01. The CC VD was reduced compared to controls (p < 0.01). Quantitative analysis of the inner retinal vasculature disclosed a significant impairment of both SCP (P < 0.01) and DCP (p < 0.01) vessel density compared to the control group. The FAZ area of the patients was smaller than controls (p < 0.01). Conclusion: OCT-A examinations revealed early vascular abnormalities in both inner retinal layers and choriocapillaris. A reduced vascular flow was also detectable in the presence of a preserved macular RPE at the color fundus, FA, and OCT examinations. OCT-A is clinically useful for evaluating early involvement of the retinal and choriocapillaris vascular network in choroideremia.
Original language | English |
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Pages (from-to) | 201-206 |
Number of pages | 6 |
Journal | Ophthalmic genetics |
Volume | 40 |
Issue number | 3 |
DOIs | |
Publication status | Published - 04 May 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019, © 2019 Taylor & Francis Group, LLC.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
Keywords
- CHM
- Choroideremia
- OCT angiography
- OCTA
- retinal dystrophies
- vessel density
- young
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Ophthalmology
- Genetics(clinical)