Optical coherence tomography features of polypoidal lesion closure in polypoidal choroidal vasculopathy treated with Aflibercept

Anna C. S. Tan, Janice Marie Jordan-Yu, Chinmayi Himanshuroy Vyas, Alfred Tau Liang Gan, Kelvin Yi Chong Teo, ChoI Mun Chan, Ranjana Mathur, Tien Yin Wong, Usha Chakravarthy, Gemmy Chui Ming Cheung

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Purpose: To evaluate whether optical coherence tomography (OCT) can determine polypoidal lesion (PL) perfusion in polypoidal choroidal vasculopathy eyes after 12 months of aflibercept monotherapy. Polypoidal lesion perfusion status, assessed by indocyanine green angiography, is an important anatomical outcome in polypoidal choroidal vasculopathy management. Methods: Post hoc data from a prospective randomized, open-label, study in eyes with polypoidal choroidal vasculopathy undergoing monotherapy with aflibercept evaluated PL perfusion status based on indocyanine green angiography (gold standard) and OCT features from baseline to 12 months. Results: Individual PLs (110 in total) from 48 eyes (48 patients) showed at 12 months; 57/110 PLs (51.8%) were closed on indocyanine green angiography. At 12 months, eyes with closed PLs were more likely to have the following OCT features: 1) no subretinal fluid (67.1% vs. 32.9%), 2) smaller pigment epithelial detachment height (67.2 [±43.8] vs. 189.2 [±104.9] μm), 3) densely hyperreflective pigment epithelial detachment contents (84.0% vs. 16.0%), 4) an absence of a hyperreflective ring(64.0% vs. 36.0%), and a 5) indistinct overlying retinal pigment epithelial (71.4% vs. 28.6%) (all P < 0.05). The three highest performing OCT features that differentiated perfused from closed PLs were (1), (3), and (4) (area under the receiver operating characteristic curve 0.85, 0.73, and 0.70, respectively). A combination of these three features achieved an area under the receiver operating characteristic curve of 0.90. Conclusion: Polypoidal lesion closure, an important anatomical treatment outcome in polypoidal choroidal vasculopathy typically defined by indocyanine green angiography, can be accurately detected by specific OCT features.
Original languageEnglish
Pages (from-to)114-122
Number of pages9
JournalRetina
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Ophthalmology
  • General Medicine

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