Optimisation of a two-liquid component pre-filled acrylic bone cement system: A design of experiments approach to optimise cement final properties

James Clements, Gavin Walker, Sreekanth Pentlavalli, Nicholas Dunne

Research output: Contribution to journalArticle

2 Citations (Scopus)
332 Downloads (Pure)

Abstract

The initial composition of acrylic bone cement along with the mixing and delivery technique used can influence its final properties and therefore its clinical success in vivo. The polymerisation of acrylic bone cement is complex with a number of processes happening simultaneously. Acrylic bone cement mixing and delivery systems have undergone several design changes in their advancement, although the cement constituents themselves have remained unchanged since they were first used. This study was conducted to determine the factors that had the greatest effect on the final properties of acrylic bone cement using a pre-filled bone cement mixing and delivery system. A design of experiments (DoE) approach was used to determine the impact of the factors associated with this mixing and delivery method on the final properties of the cement produced. The DoE illustrated that all factors present within this study had a significant impact on the final properties of the cement. An optimum cement composition was hypothesised and tested. This optimum recipe produced cement with final mechanical and thermal properties within the clinical guidelines and stated by ISO 5833 (International Standard Organisation (ISO), International standard 5833: implants for surgery—acrylic resin cements, 2002), however the low setting times observed would not be clinically viable and could result in complications during the surgical technique. As a result further development would be required to improve the setting time of the cement in order for it to be deemed suitable for use in total joint replacement surgery.
Original languageEnglish
Pages (from-to)2287-2296
Number of pages10
JournalJournal of Materials Science: Materials in Medicine
Volume25
Issue number10
Early online date09 Jul 2014
DOIs
Publication statusPublished - Oct 2014
EventSelected papers from the 1st International Conference MiMe – Materials in Medicine - Faenza, Italy
Duration: 08 Oct 201311 Oct 2013

Bibliographical note

Selected papers from the 1st International Conference MiMe – Materials in Medicine, Faenza, Italy, October 2013

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