Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate

M.J. Slater, E.M. Amphlett, D.M. Andrews, G. Bravi, G. Burton, A.G. Cheasty, J.A. Corfield, M.R. Ellis, R.H. Fenwick, S. Fernandes, R. Guidetti, David Haigh, C.D. Hartley, P.D. Howes, D.L. Jackson, R.L. Jarvest, V.L.H. Lovegrove, K.J. Medhurst, N.R. Parry, H. PriceP. Shah, O.M.P. Singh, R. Stocker, P. Thommes, C. Wilkinson, A. Wonacott

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
Original languageEnglish
Pages (from-to)897-900
Number of pages4
JournalJournal of Medicinal Chemistry
Volume50
Issue number5
DOIs
Publication statusPublished - 08 Mar 2007

ASJC Scopus subject areas

  • Organic Chemistry

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