Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate

M.J. Slater; E.M. Amphlett; D.M. Andrews; G. Bravi; G. Burton; A.G. Cheasty; J.A. Corfield; M.R. Ellis; R.H. Fenwick; S. Fernandes; R. Guidetti; David Haigh; C.D. Hartley; P.D. Howes; D.L. Jackson; R.L. Jarvest; V.L.H. Lovegrove; K.J. Medhurst; N.R. Parry; H. Price; P. Shah; O.M.P. Singh; R. Stocker; P. Thommes; C. Wilkinson; A. Wonacott

doi:10.1021/jm061207r

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate

M.J. Slater, E.M. Amphlett, D.M. Andrews, G. Bravi, G. Burton, A.G. Cheasty, J.A. Corfield, M.R. Ellis, R.H. Fenwick, S. Fernandes, R. Guidetti, David Haigh, C.D. Hartley, P.D. Howes, D.L. Jackson, R.L. Jarvest, V.L.H. Lovegrove, K.J. Medhurst, N.R. Parry, H. PriceP. Shah, O.M.P. Singh, R. Stocker, P. Thommes, C. Wilkinson, A. Wonacott

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.

Original language	English
Pages (from-to)	897-900
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	50
Issue number	5
DOIs	https://doi.org/10.1021/jm061207r
Publication status	Published - 08 Mar 2007

ASJC Scopus subject areas

Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jm061207r

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Slater, M. J., Amphlett, E. M., Andrews, D. M., Bravi, G., Burton, G., Cheasty, A. G., Corfield, J. A., Ellis, M. R., Fenwick, R. H., Fernandes, S., Guidetti, R., Haigh, D., Hartley, C. D., Howes, P. D., Jackson, D. L., Jarvest, R. L., Lovegrove, V. L. H., Medhurst, K. J., Parry, N. R., ... Wonacott, A. (2007). Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate. Journal of Medicinal Chemistry, 50(5), 897-900. https://doi.org/10.1021/jm061207r

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title = "Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate",

abstract = "Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.",

author = "M.J. Slater and E.M. Amphlett and D.M. Andrews and G. Bravi and G. Burton and A.G. Cheasty and J.A. Corfield and M.R. Ellis and R.H. Fenwick and S. Fernandes and R. Guidetti and David Haigh and C.D. Hartley and P.D. Howes and D.L. Jackson and R.L. Jarvest and V.L.H. Lovegrove and K.J. Medhurst and N.R. Parry and H. Price and P. Shah and O.M.P. Singh and R. Stocker and P. Thommes and C. Wilkinson and A. Wonacott",

year = "2007",

month = mar,

day = "8",

doi = "10.1021/jm061207r",

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Slater, MJ, Amphlett, EM, Andrews, DM, Bravi, G, Burton, G, Cheasty, AG, Corfield, JA, Ellis, MR, Fenwick, RH, Fernandes, S, Guidetti, R, Haigh, D, Hartley, CD, Howes, PD, Jackson, DL, Jarvest, RL, Lovegrove, VLH, Medhurst, KJ, Parry, NR, Price, H, Shah, P, Singh, OMP, Stocker, R, Thommes, P, Wilkinson, C & Wonacott, A 2007, 'Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate', Journal of Medicinal Chemistry, vol. 50, no. 5, pp. 897-900. https://doi.org/10.1021/jm061207r

TY - JOUR

T1 - Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate

AU - Slater, M.J.

AU - Amphlett, E.M.

AU - Andrews, D.M.

AU - Bravi, G.

AU - Burton, G.

AU - Cheasty, A.G.

AU - Corfield, J.A.

AU - Ellis, M.R.

AU - Fenwick, R.H.

AU - Fernandes, S.

AU - Guidetti, R.

AU - Haigh, David

AU - Hartley, C.D.

AU - Howes, P.D.

AU - Jackson, D.L.

AU - Jarvest, R.L.

AU - Lovegrove, V.L.H.

AU - Medhurst, K.J.

AU - Parry, N.R.

AU - Price, H.

AU - Shah, P.

AU - Singh, O.M.P.

AU - Stocker, R.

AU - Thommes, P.

AU - Wilkinson, C.

AU - Wonacott, A.

PY - 2007/3/8

Y1 - 2007/3/8

N2 - Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.

AB - Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.

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U2 - 10.1021/jm061207r

DO - 10.1021/jm061207r

M3 - Article

SN - 0022-2623

VL - 50

SP - 897

EP - 900

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 5

ER -

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate

Abstract

ASJC Scopus subject areas

UN SDGs

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