Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

Essyrose Mathew, Giulia Pitzanti, Ana L Gomes dos Santos , Dimitrios Lamprou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for the delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick and efficient method for the fabrication of hollow MN arrays.
Original languageEnglish
Article number1837
JournalPharmaceutics
Volume13
Issue number11
DOIs
Publication statusPublished - 02 Nov 2021

Keywords

  • Hollow Microneedles
  • Transdermal drug delivery
  • 3D Printing
  • Additive Manufacturing
  • Digital Light Processing
  • Emerging Technologies

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