Oral prednisolone and warfarin and risk of oesophageal cancer: a case-control study

Chris R. Cardwell*, Ronald D. McDowell, Carmel M. Hughes, John Busby, Peter Murchie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Background
A recent epidemiological study systematically screened 250 prescription medications for associations with oesophageal cancer risk, using Scottish data, and identified an increased risk with use of prednisolone and warfarin. We investigated whether oral prednisolone or warfarin use was associated with increased oesophageal cancer risk.

Methods
A case-control study was conducted within the Clinical Practice Research Datalink. In the primary analysis oesophageal cancer cases were identified from linked cancer registry records. Up to 5 cancer-free controls were matched to each case (based upon sex, birth year, GP practice and year of GP registration). Prednisolone and warfarin medications were identified from prescribing records. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression after adjusting for covariates including demographics, comorbidities and medication use.

Results
There were 4552 oesophageal cancer cases and 22,601 matched control participants. Overall, there was no evidence of an increased risk of oesophageal cancer with oral prednisolone use (unadjusted OR=1.16 95% CI 1.06, 1.27 and adjusted OR=0.99 95% CI 0.89, 1.11) or warfarin use (unadjusted OR=1.12 95% CI 0.99, 1.28 and adjusted OR=1.08 95% CI 0.92, 1.27).

Conclusions
In this large population-based study, oral prednisolone and warfarin were not associated with oesophageal cancer risk.

Original languageEnglish
Article number102552
Number of pages7
JournalCancer Epidemiology
Volume90
Early online date06 Mar 2024
DOIs
Publication statusPublished - Jun 2024

Keywords

  • Corticosteroids
  • Epidemiology
  • Oesophageal cancer
  • Prednisolone
  • Warfarin

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

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