Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

João C F Nogueira; Michelle K Greene; Daniel A Richards; Alexander O Furby; John Steven; Andrew Porter; Caroline Barelle; Christopher J Scott; Vijay Chudasama

doi:10.1039/c9cc02655j

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

João C F Nogueira, Michelle K Greene, Daniel A Richards, Alexander O Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J Scott, Vijay Chudasama

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

74 Downloads (Pure)

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

Original language	English
Pages (from-to)	7671-7674
Journal	Chemical Communications
Volume	55
Issue number	53
DOIs	https://doi.org/10.1039/c9cc02655j
Publication status	Published - 27 Jun 2019

Access to Document

10.1039/c9cc02655jLicence: CC BY

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.99 MBLicence: CC BY

Fingerprint Dive into the research topics of 'Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance'. Together they form a unique fingerprint.

Cite this

Nogueira, João C F ; Greene, Michelle K ; Richards, Daniel A ; Furby, Alexander O ; Steven, John ; Porter, Andrew ; Barelle, Caroline ; Scott, Christopher J ; Chudasama, Vijay. / Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. In: Chemical Communications. 2019 ; Vol. 55, No. 53. pp. 7671-7674.

@article{cf669119267f462cbfef547ea808c239,

title = "Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance",

abstract = "Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.",

author = "Nogueira, {Jo{\~a}o C F} and Greene, {Michelle K} and Richards, {Daniel A} and Furby, {Alexander O} and John Steven and Andrew Porter and Caroline Barelle and Scott, {Christopher J} and Vijay Chudasama",

year = "2019",

month = jun,

day = "27",

doi = "10.1039/c9cc02655j",

language = "English",

volume = "55",

pages = "7671--7674",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "53",

}

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. / Nogueira, João C F; Greene, Michelle K; Richards, Daniel A; Furby, Alexander O; Steven, John; Porter, Andrew; Barelle, Caroline; Scott, Christopher J; Chudasama, Vijay.

In: Chemical Communications, Vol. 55, No. 53, 27.06.2019, p. 7671-7674.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

AU - Nogueira, João C F

AU - Greene, Michelle K

AU - Richards, Daniel A

AU - Furby, Alexander O

AU - Steven, John

AU - Porter, Andrew

AU - Barelle, Caroline

AU - Scott, Christopher J

AU - Chudasama, Vijay

PY - 2019/6/27

Y1 - 2019/6/27

N2 - Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

AB - Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

U2 - 10.1039/c9cc02655j

DO - 10.1039/c9cc02655j

M3 - Article

C2 - 31204425

VL - 55

SP - 7671

EP - 7674

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 53

ER -