Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

João C F Nogueira, Michelle K Greene, Daniel A Richards, Alexander O Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J Scott, Vijay Chudasama

Research output: Contribution to journalArticle

2 Citations (Scopus)
53 Downloads (Pure)

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

Original languageEnglish
Pages (from-to)7671-7674
JournalChemical Communications
Volume55
Issue number53
DOIs
Publication statusPublished - 27 Jun 2019

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glycolic acid
Nanoconjugates
Antigen Receptors
Lactic acid
Antigens
Polyethylene glycols
Nanoparticles
Proteins
Acids
Tumors
Ligands

Cite this

Nogueira, João C F ; Greene, Michelle K ; Richards, Daniel A ; Furby, Alexander O ; Steven, John ; Porter, Andrew ; Barelle, Caroline ; Scott, Christopher J ; Chudasama, Vijay. / Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. In: Chemical Communications. 2019 ; Vol. 55, No. 53. pp. 7671-7674.
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Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. / Nogueira, João C F; Greene, Michelle K; Richards, Daniel A; Furby, Alexander O; Steven, John; Porter, Andrew; Barelle, Caroline; Scott, Christopher J; Chudasama, Vijay.

In: Chemical Communications, Vol. 55, No. 53, 27.06.2019, p. 7671-7674.

Research output: Contribution to journalArticle

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AU - Furby, Alexander O

AU - Steven, John

AU - Porter, Andrew

AU - Barelle, Caroline

AU - Scott, Christopher J

AU - Chudasama, Vijay

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