Abstract
Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
| Original language | English |
|---|---|
| Pages (from-to) | 7671-7674 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 53 |
| DOIs | |
| Publication status | Published - 27 Jun 2019 |
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Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. / Nogueira, João C F; Greene, Michelle K; Richards, Daniel A; Furby, Alexander O; Steven, John; Porter, Andrew; Barelle, Caroline; Scott, Christopher J; Chudasama, Vijay.
In: Chemical Communications, Vol. 55, No. 53, 27.06.2019, p. 7671-7674.Research output: Contribution to journal › Article
TY - JOUR
T1 - Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance
AU - Nogueira, João C F
AU - Greene, Michelle K
AU - Richards, Daniel A
AU - Furby, Alexander O
AU - Steven, John
AU - Porter, Andrew
AU - Barelle, Caroline
AU - Scott, Christopher J
AU - Chudasama, Vijay
PY - 2019/6/27
Y1 - 2019/6/27
N2 - Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
AB - Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
U2 - 10.1039/c9cc02655j
DO - 10.1039/c9cc02655j
M3 - Article
C2 - 31204425
VL - 55
SP - 7671
EP - 7674
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 53
ER -