Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

João C F Nogueira, Michelle K Greene, Daniel A Richards, Alexander O Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J Scott, Vijay Chudasama

Research output: Contribution to journalArticle

6 Citations (Scopus)
105 Downloads (Pure)

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

Original languageEnglish
Pages (from-to)7671-7674
JournalChemical Communications
Volume55
Issue number53
DOIs
Publication statusPublished - 27 Jun 2019

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