Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

João C F Nogueira; Michelle K Greene; Daniel A Richards; Alexander O Furby; John Steven; Andrew Porter; Caroline Barelle; Christopher J Scott; Vijay Chudasama

doi:10.1039/c9cc02655j

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

João C F Nogueira, Michelle K Greene, Daniel A Richards, Alexander O Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J Scott, Vijay Chudasama

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article

6 Citations (Scopus)

105 Downloads (Pure)

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

Original language	English
Pages (from-to)	7671-7674
Journal	Chemical Communications
Volume	55
Issue number	53
DOIs	https://doi.org/10.1039/c9cc02655j
Publication status	Published - 27 Jun 2019

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10.1039/c9cc02655jLicence: CC BY

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.99 MBLicence: CC BY

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Nogueira, João C F ; Greene, Michelle K ; Richards, Daniel A ; Furby, Alexander O ; Steven, John ; Porter, Andrew ; Barelle, Caroline ; Scott, Christopher J ; Chudasama, Vijay. / Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. In: Chemical Communications. 2019 ; Vol. 55, No. 53. pp. 7671-7674.

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abstract = "Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.",

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Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance. / Nogueira, João C F; Greene, Michelle K; Richards, Daniel A; Furby, Alexander O; Steven, John; Porter, Andrew; Barelle, Caroline; Scott, Christopher J; Chudasama, Vijay.

In: Chemical Communications, Vol. 55, No. 53, 27.06.2019, p. 7671-7674.

Research output: Contribution to journal › Article

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AU - Steven, John

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AU - Scott, Christopher J

AU - Chudasama, Vijay

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AB - Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

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