Origin of blood cells and HSC production in the embryo

Guilherme Costa; Valerie Kouskoff; Georges Lacaud

doi:10.1016/j.it.2012.01.012

Origin of blood cells and HSC production in the embryo

Guilherme Costa, Valerie Kouskoff, Georges Lacaud

Research output: Contribution to journal › Review article › peer-review

72 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming.

Original language	English
Pages (from-to)	215-223
Number of pages	9
Journal	Trends in Immunology
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.it.2012.01.012
Publication status	Published - 01 May 2012
Externally published	Yes

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AU - Kouskoff, Valerie

AU - Lacaud, Georges

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N2 - Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming.

AB - Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming.

U2 - 10.1016/j.it.2012.01.012

DO - 10.1016/j.it.2012.01.012

M3 - Review article

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JO - Trends in Immunology

JF - Trends in Immunology

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ER -

Origin of blood cells and HSC production in the embryo

Abstract

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