Outgrown asthma does not mean no airways inflammation

Madeleine Ennis, V. Brown, T.J. Warke, P.S. Fitch, R. Taylor, J.D. Lyons, Michael Shields

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Although some asthmatic children seem to recover from their asthma, 30–80% develop asthma again in later life. The underlying risk factors are unknown. The hypothesis for this study was that children with apparently outgrown asthma would have underlying airway inflammation. Nonbronchoscopic bronchoalveolar lavage was performed on normal children (n=35) and children who had wheezed previously (n=35). Eosinophils were raised in the lavage fluid of atopic children who had apparently outgrown asthma (median (interquartile range) 0.36 (0.05–0.74) compared to controls 0.10 (0–0.18), p=0.002). There was no relationship between length of remission and degree of airways eosinophilia. Thus, there is persistent airways inflammation in some children with outgrown asthma and this may be a risk factor for future relapse.
Original languageEnglish
Pages (from-to)284-287
Number of pages4
JournalEuropean Respiratory Journal
Volume19(2)
Issue number2
DOIs
Publication statusPublished - Feb 2002

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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