Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes

S. Sun, J.M. Zimmet, P. Toselli, Alexander Thompson, C.W. Jackson, K. Ravid

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background and Objectives. Megakalyocytes undergo a unique cell cycle by which they replicate their complete genome many times in the absence of cytokinesis, In the search for regulators of the endomitotic cell cycle, we previously produced mice transgenic for cyclin D3 to identify this cyclin as able to enhance ploidy and to increase the number of differentiated cells in the megakaryocytic lineage. Of the D-type cyclins, cyclin D3 and to a much lesser extent cyclin D1, are present in megakaryocytes undergoing endomitosis and these cyclins are, respectively, markedly and moderately upregulated following exposure to the ploidy-promoting factor, Mpl-ligand. Our objective was to explore whether cyclin D1 can mimic the effect of cyclin D3 on ploidy in megakalyocytes.
Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalHAEMATOLOGICA
Volume86
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Hematology

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