Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies

Ailbhe A. Ryan; Seán D. Dempsey; Megan Smyth; Karen Fahey; Thomas S. Moody; Scott Wharry; Paul Dingwall; David W. Rooney; Jillian M. Thompson; Peter C. Knipe; Mark J. Muldoon

doi:10.1002/cctc.202301709

Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies

Ailbhe A. Ryan, Seán D. Dempsey, Megan Smyth, Karen Fahey, Thomas S. Moody, Scott Wharry, Paul Dingwall, David W. Rooney, Jillian M. Thompson^*, Peter C. Knipe^*, Mark J. Muldoon^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

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Abstract

A homogeneous catalyst system consisting of Mn(OAc)₂ and 2-picolinic acid was studied for alcohol oxidation using peracetic acid as the oxidant. Catalyst loadings as low as 0.01 mol% could be utilized and the system compared well to other peroxide based methods. The utilization of continuous flow allowed the fast, exothermic reactions to be carried out in a safe and scalable manner.

Original language	English
Article number	e202301709
Number of pages	9
Journal	ChemCatChem
Early online date	28 Jun 2024
DOIs	https://doi.org/10.1002/cctc.202301709
Publication status	Early online date - 28 Jun 2024

Keywords

Continuous flow
carbonyls
manganese
oxidation
peroxide

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10.1002/cctc.202301709Licence: CC BY

Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies
Copyright 2024 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 3.94 MBLicence: CC BY

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Ryan, A. A., Dempsey, S. D., Smyth, M., Fahey, K., Moody, T. S., Wharry, S., Dingwall, P., Rooney, D. W., Thompson, J. M., Knipe, P. C., & Muldoon, M. J. (2024). Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies. ChemCatChem, Article e202301709. Advance online publication. https://doi.org/10.1002/cctc.202301709

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title = "Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies",

abstract = "A homogeneous catalyst system consisting of Mn(OAc)2 and 2-picolinic acid was studied for alcohol oxidation using peracetic acid as the oxidant. Catalyst loadings as low as 0.01 mol% could be utilized and the system compared well to other peroxide based methods. The utilization of continuous flow allowed the fast, exothermic reactions to be carried out in a safe and scalable manner.",

keywords = "Continuous flow, carbonyls, manganese, oxidation, peroxide",

author = "Ryan, {Ailbhe A.} and Dempsey, {Se{\'a}n D.} and Megan Smyth and Karen Fahey and Moody, {Thomas S.} and Scott Wharry and Paul Dingwall and Rooney, {David W.} and Thompson, {Jillian M.} and Knipe, {Peter C.} and Muldoon, {Mark J.}",

year = "2024",

month = jun,

day = "28",

doi = "10.1002/cctc.202301709",

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T1 - Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies

AU - Ryan, Ailbhe A.

AU - Dempsey, Seán D.

AU - Smyth, Megan

AU - Fahey, Karen

AU - Moody, Thomas S.

AU - Wharry, Scott

AU - Dingwall, Paul

AU - Rooney, David W.

AU - Thompson, Jillian M.

AU - Knipe, Peter C.

AU - Muldoon, Mark J.

PY - 2024/6/28

Y1 - 2024/6/28

N2 - A homogeneous catalyst system consisting of Mn(OAc)2 and 2-picolinic acid was studied for alcohol oxidation using peracetic acid as the oxidant. Catalyst loadings as low as 0.01 mol% could be utilized and the system compared well to other peroxide based methods. The utilization of continuous flow allowed the fast, exothermic reactions to be carried out in a safe and scalable manner.

AB - A homogeneous catalyst system consisting of Mn(OAc)2 and 2-picolinic acid was studied for alcohol oxidation using peracetic acid as the oxidant. Catalyst loadings as low as 0.01 mol% could be utilized and the system compared well to other peroxide based methods. The utilization of continuous flow allowed the fast, exothermic reactions to be carried out in a safe and scalable manner.

KW - Continuous flow

KW - carbonyls

KW - manganese

KW - oxidation

KW - peroxide

U2 - 10.1002/cctc.202301709

DO - 10.1002/cctc.202301709

M3 - Article

SN - 1867-3899

JO - ChemCatChem

JF - ChemCatChem

M1 - e202301709

ER -

Oxidation of alcohols and aldehydes with peracetic acid and a Mn(II)/Pyridin‐2‐carboxylato catalyst: substrate and continuous flow studies

Abstract

Keywords

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