Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells

Mingyuan Wu, Shihe Yang, Michael H Elliott, Dongxu Fu, Kenneth Wilson, Jing Zhang, Mei Du, Junping Chen, Timothy Lyons

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells.
Original languageEnglish
Pages (from-to)4595-604
Number of pages10
JournalInvestigative ophthalmology & visual science
Volume53
Issue number8
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Adult
  • Apoptosis
  • Blotting, Western
  • Cell Survival
  • Cells, Cultured
  • Diabetic Retinopathy
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Female
  • Glycosylation
  • Humans
  • In Situ Nick-End Labeling
  • Lipoproteins, LDL
  • Male
  • Middle Aged
  • Neuroglia
  • Oxidation-Reduction
  • Oxidative Stress
  • Retinal Ganglion Cells
  • Young Adult

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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