Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells

Mingyuan Wu; Shihe Yang; Michael H Elliott; Dongxu Fu; Kenneth Wilson; Jing Zhang; Mei Du; Junping Chen; Timothy Lyons

doi:10.1167/iovs.12-9910

Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells

Mingyuan Wu, Shihe Yang, Michael H Elliott, Dongxu Fu, Kenneth Wilson, Jing Zhang, Mei Du, Junping Chen, Timothy Lyons

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells.

Original language	English
Pages (from-to)	4595-604
Number of pages	10
Journal	Investigative ophthalmology & visual science
Volume	53
Issue number	8
DOIs	https://doi.org/10.1167/iovs.12-9910
Publication status	Published - Jul 2012

Keywords

Adult
Apoptosis
Blotting, Western
Cell Survival
Cells, Cultured
Diabetic Retinopathy
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Female
Glycosylation
Humans
In Situ Nick-End Labeling
Lipoproteins, LDL
Male
Middle Aged
Neuroglia
Oxidation-Reduction
Oxidative Stress
Retinal Ganglion Cells
Young Adult

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1167/iovs.12-9910

Cite this

@article{381e2ebb0a0d4138801ea52d02fed0f4,

title = "Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal M{\"u}ller cells",

abstract = "We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal M{\"u}ller glial cells.",

keywords = "Adult, Apoptosis, Blotting, Western, Cell Survival, Cells, Cultured, Diabetic Retinopathy, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Female, Glycosylation, Humans, In Situ Nick-End Labeling, Lipoproteins, LDL, Male, Middle Aged, Neuroglia, Oxidation-Reduction, Oxidative Stress, Retinal Ganglion Cells, Young Adult",

author = "Mingyuan Wu and Shihe Yang and Elliott, {Michael H} and Dongxu Fu and Kenneth Wilson and Jing Zhang and Mei Du and Junping Chen and Timothy Lyons",

year = "2012",

month = jul,

doi = "10.1167/iovs.12-9910",

language = "English",

volume = "53",

pages = "4595--604",

journal = "Investigative Opthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "8",

}

TY - JOUR

T1 - Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells

AU - Wu, Mingyuan

AU - Yang, Shihe

AU - Elliott, Michael H

AU - Fu, Dongxu

AU - Wilson, Kenneth

AU - Zhang, Jing

AU - Du, Mei

AU - Chen, Junping

AU - Lyons, Timothy

PY - 2012/7

Y1 - 2012/7

N2 - We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells.

AB - We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells.

KW - Adult

KW - Apoptosis

KW - Blotting, Western

KW - Cell Survival

KW - Cells, Cultured

KW - Diabetic Retinopathy

KW - Endoplasmic Reticulum

KW - Endoplasmic Reticulum Stress

KW - Female

KW - Glycosylation

KW - Humans

KW - In Situ Nick-End Labeling

KW - Lipoproteins, LDL

KW - Male

KW - Middle Aged

KW - Neuroglia

KW - Oxidation-Reduction

KW - Oxidative Stress

KW - Retinal Ganglion Cells

KW - Young Adult

U2 - 10.1167/iovs.12-9910

DO - 10.1167/iovs.12-9910

M3 - Article

C2 - 22678501

VL - 53

SP - 4595

EP - 4604

JO - Investigative Opthalmology and Visual Science

JF - Investigative Opthalmology and Visual Science

SN - 0146-0404

IS - 8

ER -

Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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