Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage fluid from newborn babies

B.C. Schock, D.G. Sweet, Madeleine Ennis, J.A. Warner, Ian Young, H.L. Halliday

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Oxidative stress may increase lung permeability by upregulation of matrix-metalloproteinase-9 (MMP-8), a type-IV collagenase that can disrupt alveolar basement membranes. We have compared a marker of oxidative stress (protein carbonyl residues) with levels of MMP-8 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), in bronchoalveolar lavage samples from newborn babies. Bronchoalveolar lavage samples (n = 87, two from each time point) were taken in the first 6 postnatal days from 41 ventilated babies: 18 of
Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalPediatric Research
Volume50
Issue number1 I
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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