Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage fluid from newborn babies

B.C. Schock; D.G. Sweet; Madeleine Ennis; J.A. Warner; Ian Young; H.L. Halliday

Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage fluid from newborn babies

B.C. Schock, D.G. Sweet, Madeleine Ennis, J.A. Warner, Ian Young, H.L. Halliday

Research output: Contribution to journal › Article

Abstract

Oxidative stress may increase lung permeability by upregulation of matrix-metalloproteinase-9 (MMP-8), a type-IV collagenase that can disrupt alveolar basement membranes. We have compared a marker of oxidative stress (protein carbonyl residues) with levels of MMP-8 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), in bronchoalveolar lavage samples from newborn babies. Bronchoalveolar lavage samples (n = 87, two from each time point) were taken in the first 6 postnatal days from 41 ventilated babies: 18 of

Original language	English
Pages (from-to)	29-33
Number of pages	5
Journal	Pediatric Research
Volume	50
Issue number	1 I
Publication status	Published - 2001

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage fluid from newborn babies",

abstract = "Oxidative stress may increase lung permeability by upregulation of matrix-metalloproteinase-9 (MMP-8), a type-IV collagenase that can disrupt alveolar basement membranes. We have compared a marker of oxidative stress (protein carbonyl residues) with levels of MMP-8 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), in bronchoalveolar lavage samples from newborn babies. Bronchoalveolar lavage samples (n = 87, two from each time point) were taken in the first 6 postnatal days from 41 ventilated babies: 18 of",

author = "B.C. Schock and D.G. Sweet and Madeleine Ennis and J.A. Warner and Ian Young and H.L. Halliday",

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AU - Schock, B.C.

AU - Sweet, D.G.

AU - Ennis, Madeleine

AU - Warner, J.A.

AU - Young, Ian

AU - Halliday, H.L.

PY - 2001

Y1 - 2001

N2 - Oxidative stress may increase lung permeability by upregulation of matrix-metalloproteinase-9 (MMP-8), a type-IV collagenase that can disrupt alveolar basement membranes. We have compared a marker of oxidative stress (protein carbonyl residues) with levels of MMP-8 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), in bronchoalveolar lavage samples from newborn babies. Bronchoalveolar lavage samples (n = 87, two from each time point) were taken in the first 6 postnatal days from 41 ventilated babies: 18 of

AB - Oxidative stress may increase lung permeability by upregulation of matrix-metalloproteinase-9 (MMP-8), a type-IV collagenase that can disrupt alveolar basement membranes. We have compared a marker of oxidative stress (protein carbonyl residues) with levels of MMP-8 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), in bronchoalveolar lavage samples from newborn babies. Bronchoalveolar lavage samples (n = 87, two from each time point) were taken in the first 6 postnatal days from 41 ventilated babies: 18 of

M3 - Article

VL - 50

SP - 29

EP - 33

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 1 I

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