Oxidative stress and inflammation in lean and obese subjects with polycystic ovary syndrome

Sarah A Blair, Tommy Kyaw-Tun, Ian S Young, Niamh A Phelan, James Gibney, Jane McEneny

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)



To determine whether polycystic ovary syndrome (PCOS) independently influences oxidative stress and inflammation or if the culprit is the comorbidities of obesity and/or insulin resistance common to this condition.


Thirty women with PCOS were matched for age, body mass index and insulin resistance with 30 control subjects. Oxidative stress was examined by measuring the total oxidant status (TOS) and total antioxidant capacity (TAC) by spectrophotometric assay. The inflammatory biomarkers, C-reactive protein, plasminogen activator inhibitor-1, myeloperoxidase, neopterin, and serum amyloid A were measured by ELISA methodologies.


Oxidative status was increased in the PCOS subjects relative to their weight-matched controls (TOS: obese PCOS patients vs. obese controls, 42.42 +/- 4.49 vs. 32.57 +/- 1.97, p<0.05; lean PCOS patients vs. lean controls, 33.69 +/- 1.59 vs. 28.69 +/- 1.18 micromol H2O2 Equiv/L, p < 0.05). Furthermore, antioxidant capacity was lower in the lean PCOS group relative to their weight-matched controls (TAC: lean PCOS patients vs. lean controls, 1.10 +/- 0.09 vs. 1.49 +/- 0.03 nmol Trolox Equiv/L, p < 0.05).


These results suggest that PCOS independently influenced oxidative stress. Overall, the presence of PCOS may increase cardiovascular risk.

Original languageEnglish
Pages (from-to)107-114
JournalThe Journal of reproductive medicine
Issue number3-4
Publication statusPublished - Apr 2013


  • Adult
  • Analysis of Variance
  • Antioxidants
  • C-Reactive Protein
  • Case-Control Studies
  • Female
  • Humans
  • Inflammation
  • Neopterin
  • Obesity
  • Oxidative Stress
  • Peroxidase
  • Plasminogen Activator Inhibitor 1
  • Polycystic Ovary Syndrome
  • Serum Amyloid A Protein
  • Statistics, Nonparametric

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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