Abstract
This Letter describes the further development and SAR exploration of a novel series of Legumain inhibitors. Based upon a previously identified Legumain inhibitor from our group, we explored the SAR of the carbamate phenyl ring system to probe the P3 pocket of the enzyme. This led to the identification of a sub-nanomolar inhibitor of Legumain.
Original language | English |
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Pages (from-to) | 2521-2524 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 24 |
Issue number | 11 |
Early online date | 12 Apr 2014 |
DOIs | |
Publication status | Published - 01 Jun 2014 |