Paediatric deaths in a tertiary government hospital setting, Malawi

Caroline Harris, Rowena Mills, Ezgi Seager, Sarah Blackstock, Tamanda Hiwa, James Pumphrey, Josephine Langton, Neil Kennedy

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


BACKGROUND: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

AIMS: To determine the causes of inpatient child death including microbiological aetiologies in Malawi.

METHODS: A prospective, descriptive study was undertaken in Queen Elizabeth Central Hospital over 12 months in 2015/2016. Data was collected for every paediatric covering HIV and nutritional status, cause of death, and microbiology. Deaths of inborn neonates were excluded.

RESULTS: Of 13,827 admissions, there were 488 deaths, giving a mortality rate of 3.5%. One-third of deaths (168) occurred in the first 24 h of admission and 255 after 48 h Sixty-eight per cent of those who died (332) were under 5 years of age. The five leading causes of death were sepsis (102), lower respiratory tract infection (67), acute gastroenteritis with severe dehydration (51), malaria (37) and meningitis (34). The leading non-communicable cause of death was solid tumour (12). Of the 362 children with a known HIV status 134 (37.0%) were HIV-infected or HIV-exposed. Of the 429 children with a known nutrional status, 93 had evidence of severe acute malnutrition (SAM). Blood cultures were obtained from 252 children 51 (20.2%) grew pathogenic bacteria with Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus being the most common.

CONCLUSION: Despite a significant reduction in paediatric inpatient mortality in Malawi, infectious diseases remain the predominant cause.

Original languageEnglish
Number of pages9
JournalJournal of Paediatrics and Child Health
Early online date19 Nov 2018
Publication statusEarly online date - 19 Nov 2018


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