Palladium Catalysed Decarboxylative Rearrangement of N-Alloc Indoles

Jun Chen; Matthew J. Cook

doi:10.1021/ol400110c

Palladium Catalysed Decarboxylative Rearrangement of N-Alloc Indoles

Jun Chen, Matthew J. Cook

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

A highly efficient palladium catalyzed decarboxylative allylic rearrangement of alloc indoles has been developed. This can also be combined with a Suzuki–Miyaura cross-coupling reaction in a single pot transformation. Substituted alloc groups and benzylic variants have also been demonstrated alongside promising initial results on the enantioselective variant.

Original language	English
Pages (from-to)	1088-1091
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	5
DOIs	https://doi.org/10.1021/ol400110c
Publication status	Published - Mar 2013

ASJC Scopus subject areas

Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry

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10.1021/ol400110c

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title = "Palladium Catalysed Decarboxylative Rearrangement of N-Alloc Indoles",

abstract = "A highly efficient palladium catalyzed decarboxylative allylic rearrangement of alloc indoles has been developed. This can also be combined with a Suzuki–Miyaura cross-coupling reaction in a single pot transformation. Substituted alloc groups and benzylic variants have also been demonstrated alongside promising initial results on the enantioselective variant. ",

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AB - A highly efficient palladium catalyzed decarboxylative allylic rearrangement of alloc indoles has been developed. This can also be combined with a Suzuki–Miyaura cross-coupling reaction in a single pot transformation. Substituted alloc groups and benzylic variants have also been demonstrated alongside promising initial results on the enantioselective variant.

U2 - 10.1021/ol400110c

DO - 10.1021/ol400110c

M3 - Article

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JF - Organic Letters

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IS - 5

ER -

Palladium Catalysed Decarboxylative Rearrangement of N-Alloc Indoles

Abstract

ASJC Scopus subject areas

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