A palladium-catalyzed oxidative reaction is reported which converts dihydropyrans to their corresponding ortholactone. The products are formed in good to excellent yields with a very high level of chemoselectivity and functional group tolerance. Mechanistic studies confirm that the reaction proceeds by a Wacker-type mechanism.
Baddeley, K. L., Cao, Q., Muldoon, M. J., & Cook, M. J. (2015). Palladium-Catalyzed Oxidative Synthesis of Highly Functionalized Ortholactones. Chemistry - A European Journal, 21(21), 7726-7730. https://doi.org/10.1002/chem.201500862