Abstract
2-Ynamides can be synthesised through Pd(II) catalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previous oxidative methods, which rely on dangerous solvents and gas mixtures. The use of [NBu4 ]I allows the utilisation of the industrially recommended solvent ethyl acetate. O2 can be used as the terminal oxidant, and the catalyst can operate under safer conditions with low O2 concentrations.
| Original language | English |
|---|---|
| Pages (from-to) | 675-680 |
| Number of pages | 6 |
| Journal | CHEMSUSCHEM |
| Volume | 10 |
| Issue number | 4 |
| Early online date | 23 Jan 2017 |
| DOIs | |
| Publication status | Early online date - 23 Jan 2017 |
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Keywords
- Journal Article
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Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures. / Hughes, Nicola; Brown, Clare L; Irwin, Andrew A; Cao, Qun; Muldoon, Mark J.
In: CHEMSUSCHEM, Vol. 10, No. 4, 23.01.2017, p. 675-680.Research output: Contribution to journal › Article
TY - JOUR
T1 - Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures
AU - Hughes, Nicola
AU - Brown, Clare L
AU - Irwin, Andrew A
AU - Cao, Qun
AU - Muldoon, Mark J
N1 - © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2017/1/23
Y1 - 2017/1/23
N2 - 2-Ynamides can be synthesised through Pd(II) catalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previous oxidative methods, which rely on dangerous solvents and gas mixtures. The use of [NBu4 ]I allows the utilisation of the industrially recommended solvent ethyl acetate. O2 can be used as the terminal oxidant, and the catalyst can operate under safer conditions with low O2 concentrations.
AB - 2-Ynamides can be synthesised through Pd(II) catalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previous oxidative methods, which rely on dangerous solvents and gas mixtures. The use of [NBu4 ]I allows the utilisation of the industrially recommended solvent ethyl acetate. O2 can be used as the terminal oxidant, and the catalyst can operate under safer conditions with low O2 concentrations.
KW - Journal Article
U2 - 10.1002/cssc.201601601
DO - 10.1002/cssc.201601601
M3 - Article
C2 - 27906507
VL - 10
SP - 675
EP - 680
JO - CHEMSUSCHEM
JF - CHEMSUSCHEM
SN - 1864-5631
IS - 4
ER -