Parallel G-quadruplex-mediated protein dimerization and activation

Tuom Tinh Thi Truong, Cuong Cao, Dung Thanh Dang

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Abstract

We studied parallel G4-mediated protein dimerization and activation by incorporating a RHAU peptide with a fluorescent protein FRET pair CFP/YFP and an apoptotic casp9. Occurrence of energy tranfer (from donor CFP to acceptor YFP) and enhancement of 60-fold cleavage efficiency of casp9 were observed in the presence of parallel G4, which indicated that parallel G4 can induce dimerization and activation of proteins. This novel approach holds a great promise for studyingG4-targeting functional dimeric proteins in celllular biology.
Original languageEnglish
Pages (from-to)29957-29960
Number of pages4
JournalRSC Advances
Volume10
DOIs
Publication statusPublished - 07 Aug 2020

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