Parallel G-quadruplex-mediated protein dimerization and activation

Tuom Tinh Thi Truong, Cuong Cao, Dung Thanh Dang

Research output: Contribution to journalArticlepeer-review

34 Downloads (Pure)


We studied parallel G4-mediated protein dimerization and activation by incorporating a RHAU peptide with a fluorescent protein FRET pair CFP/YFP and an apoptotic casp9. Occurrence of energy tranfer (from donor CFP to acceptor YFP) and enhancement of 60-fold cleavage efficiency of casp9 were observed in the presence of parallel G4, which indicated that parallel G4 can induce dimerization and activation of proteins. This novel approach holds a great promise for studyingG4-targeting functional dimeric proteins in celllular biology.
Original languageEnglish
Pages (from-to)29957-29960
Number of pages4
JournalRSC Advances
Publication statusPublished - 07 Aug 2020


Dive into the research topics of 'Parallel G-quadruplex-mediated protein dimerization and activation'. Together they form a unique fingerprint.

Cite this