Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients

O Hasselwander, D A Savage, D McMaster, C M Loughrey, P T McNamee, D Middleton, D P Nicholls, A P Maxwell, I S Young

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Paraoxonase (PON1) gene variants have been identified as risk factors for cardiovascular disease (CVD). There are two common PON1 polymorphisms at position 55 (Leu-Met change) and 192 (Gln-Arg change) of the amino acid chain. Leucine at position 55 and arginine at position 192 have been associated with increased cardiovascular risk. The increased prevalence of CVD in renal transplant recipients can be only partly explained by the increased prevalence of conventional risk factors.
Original languageEnglish
Pages (from-to)289-98
Number of pages10
JournalKidney International
Volume56
Issue number1
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Nephrology

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