Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients

O Hasselwander; D A Savage; D McMaster; C M Loughrey; P T McNamee; D Middleton; D P Nicholls; A P Maxwell; I S Young

doi:10.1046/j.1523-1755.1999.00521.x

Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients

O Hasselwander, D A Savage, D McMaster, C M Loughrey, P T McNamee, D Middleton, D P Nicholls, A P Maxwell, I S Young

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Paraoxonase (PON1) gene variants have been identified as risk factors for cardiovascular disease (CVD). There are two common PON1 polymorphisms at position 55 (Leu-Met change) and 192 (Gln-Arg change) of the amino acid chain. Leucine at position 55 and arginine at position 192 have been associated with increased cardiovascular risk. The increased prevalence of CVD in renal transplant recipients can be only partly explained by the increased prevalence of conventional risk factors.

Original language	English
Pages (from-to)	289-98
Number of pages	10
Journal	Kidney International
Volume	56
Issue number	1
DOIs	https://doi.org/10.1046/j.1523-1755.1999.00521.x
Publication status	Published - 1999

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1046/j.1523-1755.1999.00521.x

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title = "Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients",

abstract = "Paraoxonase (PON1) gene variants have been identified as risk factors for cardiovascular disease (CVD). There are two common PON1 polymorphisms at position 55 (Leu-Met change) and 192 (Gln-Arg change) of the amino acid chain. Leucine at position 55 and arginine at position 192 have been associated with increased cardiovascular risk. The increased prevalence of CVD in renal transplant recipients can be only partly explained by the increased prevalence of conventional risk factors.",

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T1 - Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients

AU - Hasselwander, O

AU - Savage, D A

AU - McMaster, D

AU - Loughrey, C M

AU - McNamee, P T

AU - Middleton, D

AU - Nicholls, D P

AU - Maxwell, A P

AU - Young, I S

PY - 1999

Y1 - 1999

N2 - Paraoxonase (PON1) gene variants have been identified as risk factors for cardiovascular disease (CVD). There are two common PON1 polymorphisms at position 55 (Leu-Met change) and 192 (Gln-Arg change) of the amino acid chain. Leucine at position 55 and arginine at position 192 have been associated with increased cardiovascular risk. The increased prevalence of CVD in renal transplant recipients can be only partly explained by the increased prevalence of conventional risk factors.

AB - Paraoxonase (PON1) gene variants have been identified as risk factors for cardiovascular disease (CVD). There are two common PON1 polymorphisms at position 55 (Leu-Met change) and 192 (Gln-Arg change) of the amino acid chain. Leucine at position 55 and arginine at position 192 have been associated with increased cardiovascular risk. The increased prevalence of CVD in renal transplant recipients can be only partly explained by the increased prevalence of conventional risk factors.

U2 - 10.1046/j.1523-1755.1999.00521.x

DO - 10.1046/j.1523-1755.1999.00521.x

M3 - Article

C2 - 10411705

VL - 56

SP - 289

EP - 298

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 1

ER -