Pathobiology of rabies virus and the European bat lyssaviruses in experimentally infected mice

D M Healy, S M Brookes, A C Banyard, A Núñez, S L Cosby, A R Fooks

Research output: Contribution to journalArticle

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Abstract

A comparison of the clinicopathology of European bat lyssavirus (EBLV) types-1 and -2 and of rabies virus was undertaken. Following inoculation of mice at a peripheral site with these viruses, clinical signs of rabies and distribution of virus antigen in the mouse brain were examined. The appearance of clinical signs of disease varied both within and across the different virus species, with variation in incubation periods and weight loss throughout disease progression. The distribution of viral antigen throughout the regions of the brain examined was similar for each of the isolates during the different stages of disease progression, suggesting that antigen distribution was not associated with clinical presentation. However, specific regions of the brain including the cerebellum, caudal medulla, hypothalamus and thalamus, showed notable differences in the proportion of virus antigen positive cells present in comparison to other brain regions suggesting that these areas are important in disease development irrespective of virus species.
Original languageEnglish
Pages (from-to)46-53
JournalVirus Research
Volume172
Issue number1-2
Early online date27 Dec 2012
DOIs
Publication statusPublished - Mar 2013

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Lyssavirus
Rabies virus
Viruses
Brain
Antigens
Disease Progression
Viral Antigens
Thalamus
Cerebellum
Hypothalamus
Weight Loss

Bibliographical note

Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Cite this

Healy, D M ; Brookes, S M ; Banyard, A C ; Núñez, A ; Cosby, S L ; Fooks, A R. / Pathobiology of rabies virus and the European bat lyssaviruses in experimentally infected mice. In: Virus Research. 2013 ; Vol. 172, No. 1-2. pp. 46-53.
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Pathobiology of rabies virus and the European bat lyssaviruses in experimentally infected mice. / Healy, D M; Brookes, S M; Banyard, A C; Núñez, A; Cosby, S L; Fooks, A R.

In: Virus Research, Vol. 172, No. 1-2, 03.2013, p. 46-53.

Research output: Contribution to journalArticle

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