Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants

Christopher Rayner; Jonathan R.I. Coleman; Megan Skelton; Cherie Armour; John Bradley; Joshua E.J. Buckman; Molly R. Davies; Colette R. Hirsch; Matthew Hotopf; Christopher Hübel; Ian R. Jones; Gursharan Kalsi; Nathalie Kingston; Georgina Krebs; Yuhao Lin; Dina Monssen; Andrew M. McIntosh; Jessica R. Mundy; Alicia J. Peel; Katharine A. Rimes; Henry C. Rogers; Daniel J. Smith; Abigail R. ter Kuile; Katherine N. Thompson; David Veale; Janet Wingrove; James T.R. Walters; Gerome Breen; Thalia C. Eley

doi:10.1186/s12888-022-04275-6

Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants

Christopher Rayner
, Jonathan R.I. Coleman
, Megan Skelton
, Cherie Armour
, John Bradley
, Joshua E.J. Buckman
, Molly R. Davies
, Colette R. Hirsch
, Matthew Hotopf
, Christopher Hübel
, Ian R. Jones
, Gursharan Kalsi
, Nathalie Kingston
, Georgina Krebs
, Yuhao Lin
, Dina Monssen
, Andrew M. McIntosh
, Jessica R. Mundy
, Alicia J. Peel
, Katharine A. Rimes

Henry C. Rogers, Daniel J. Smith, Abigail R. ter Kuile, Katherine N. Thompson, David Veale, Janet Wingrove, James T.R. Walters, Gerome Breen, Thalia C. Eley^*

^*Corresponding author for this work

School of Psychology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

48 Downloads (Pure)

Abstract

BACKGROUND: Progress towards stratified care for anxiety and depression will require the identification of new predictors. We collected data on retrospectively self-reported therapeutic outcomes in adults who received psychological therapy in the UK in the past ten years. We aimed to replicate factors associated with traditional treatment outcome measures from the literature.

METHODS: Participants were from the Genetic Links to Anxiety and Depression (GLAD) Study, a UK-based volunteer cohort study. We investigated associations between retrospectively self-reported outcomes following therapy, on a five-point scale (global rating of change; GRC) and a range of sociodemographic, clinical and therapy-related factors, using ordinal logistic regression models (n = 2890).

RESULTS: Four factors were associated with therapy outcomes (adjusted odds ratios, OR). One sociodemographic factor, having university-level education, was associated with favourable outcomes (OR = 1.37, 95%CI: 1.18, 1.59). Two clinical factors, greater number of reported episodes of illness (OR = 0.95, 95%CI: 0.92, 0.97) and higher levels of personality disorder symptoms (OR = 0.89, 95%CI: 0.87, 0.91), were associated with less favourable outcomes. Finally, reported regular use of additional therapeutic activities was associated with favourable outcomes (OR = 1.39, 95%CI: 1.19, 1.63). There were no statistically significant differences between fully adjusted multivariable and unadjusted univariable odds ratios.

CONCLUSION: Therapy outcome data can be collected quickly and inexpensively using retrospectively self-reported measures in large observational cohorts. Retrospectively self-reported therapy outcomes were associated with four factors previously reported in the literature. Similar data collected in larger observational cohorts may enable detection of novel associations with therapy outcomes, to generate new hypotheses, which can be followed up in prospective studies.

Original language	English
Article number	719
Number of pages	9
Journal	BMC Psychiatry
Volume	22
Early online date	18 Nov 2022
DOIs	https://doi.org/10.1186/s12888-022-04275-6
Publication status	Published - Dec 2022

Bibliographical note

Funding Information:
TCE and GB are part-funded by a program grant from the UK Medical Research Council (MR/V012878/1). CR is supported by a grant from Fondation Peters to TCE and GB. AJP is supported by an ESRC studentship. GK is funded by an MRC Clinical Research Training Fellowship (MR/N001400/1). MS is funded by an NIHR Maudsley Biomedical Research Centre studentship. CH acknowledges funding from Lundbeckfonden (R276-2018-4581). JB was funded on a clinical research fellowship from the Wellcome Trust (201292/Z/16/Z). JM is funded by the NIHR Maudsley Biomedical Research Centre and the Lord Leverhulme Charitable Grant (Professor Robin Murray). ARTK is funded by an NIHR Maudsley Biomedical Research Centre studentship. The authors also acknowledge use of the research computing facility at King’s College London, Rosalind ( https://rosalind.kcl.ac.uk ), which was part-funded by capital equipment grants from Guy’s and St Thomas’ Charity (TR130505) and Maudsley Charity (award 980).

Funding Information:
We thank all GLAD Study volunteers for their participation, and gratefully acknowledge the National Institute for Health and Care Research (NIHR) BioResource, NIHR BioResource centres, NHS Trusts and staff for their contribution. We also acknowledge King’s College London, South London and Maudsley NHS Trust and King’s Health Partners. We thank the National Institute for Health and Care Research, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.

Publisher Copyright:
© 2022, The Author(s).

Keywords

Cognitive behavioral therapy
Counselling
Minimal phenotyping

ASJC Scopus subject areas

Psychiatry and Mental health

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Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants
© 2022 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.37 MBLicence: CC BY

Cite this

Rayner, C., Coleman, J. R. I., Skelton, M., Armour, C., Bradley, J., Buckman, J. E. J., Davies, M. R., Hirsch, C. R., Hotopf, M., Hübel, C., Jones, I. R., Kalsi, G., Kingston, N., Krebs, G., Lin, Y., Monssen, D., McIntosh, A. M., Mundy, J. R., Peel, A. J., ... Eley, T. C. (2022). Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants. BMC Psychiatry, 22, Article 719. https://doi.org/10.1186/s12888-022-04275-6

@article{ee87f9644ae94ac2babc19fce4df810d,

title = "Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants",

abstract = "BACKGROUND: Progress towards stratified care for anxiety and depression will require the identification of new predictors. We collected data on retrospectively self-reported therapeutic outcomes in adults who received psychological therapy in the UK in the past ten years. We aimed to replicate factors associated with traditional treatment outcome measures from the literature.METHODS: Participants were from the Genetic Links to Anxiety and Depression (GLAD) Study, a UK-based volunteer cohort study. We investigated associations between retrospectively self-reported outcomes following therapy, on a five-point scale (global rating of change; GRC) and a range of sociodemographic, clinical and therapy-related factors, using ordinal logistic regression models (n = 2890).RESULTS: Four factors were associated with therapy outcomes (adjusted odds ratios, OR). One sociodemographic factor, having university-level education, was associated with favourable outcomes (OR = 1.37, 95\%CI: 1.18, 1.59). Two clinical factors, greater number of reported episodes of illness (OR = 0.95, 95\%CI: 0.92, 0.97) and higher levels of personality disorder symptoms (OR = 0.89, 95\%CI: 0.87, 0.91), were associated with less favourable outcomes. Finally, reported regular use of additional therapeutic activities was associated with favourable outcomes (OR = 1.39, 95\%CI: 1.19, 1.63). There were no statistically significant differences between fully adjusted multivariable and unadjusted univariable odds ratios.CONCLUSION: Therapy outcome data can be collected quickly and inexpensively using retrospectively self-reported measures in large observational cohorts. Retrospectively self-reported therapy outcomes were associated with four factors previously reported in the literature. Similar data collected in larger observational cohorts may enable detection of novel associations with therapy outcomes, to generate new hypotheses, which can be followed up in prospective studies.",

keywords = "Cognitive behavioral therapy, Counselling, Minimal phenotyping",

author = "Christopher Rayner and Coleman, \{Jonathan R.I.\} and Megan Skelton and Cherie Armour and John Bradley and Buckman, \{Joshua E.J.\} and Davies, \{Molly R.\} and Hirsch, \{Colette R.\} and Matthew Hotopf and Christopher H{\"u}bel and Jones, \{Ian R.\} and Gursharan Kalsi and Nathalie Kingston and Georgina Krebs and Yuhao Lin and Dina Monssen and McIntosh, \{Andrew M.\} and Mundy, \{Jessica R.\} and Peel, \{Alicia J.\} and Rimes, \{Katharine A.\} and Rogers, \{Henry C.\} and Smith, \{Daniel J.\} and \{ter Kuile\}, \{Abigail R.\} and Thompson, \{Katherine N.\} and David Veale and Janet Wingrove and Walters, \{James T.R.\} and Gerome Breen and Eley, \{Thalia C.\}",

note = "Funding Information: TCE and GB are part-funded by a program grant from the UK Medical Research Council (MR/V012878/1). CR is supported by a grant from Fondation Peters to TCE and GB. AJP is supported by an ESRC studentship. GK is funded by an MRC Clinical Research Training Fellowship (MR/N001400/1). MS is funded by an NIHR Maudsley Biomedical Research Centre studentship. CH acknowledges funding from Lundbeckfonden (R276-2018-4581). JB was funded on a clinical research fellowship from the Wellcome Trust (201292/Z/16/Z). JM is funded by the NIHR Maudsley Biomedical Research Centre and the Lord Leverhulme Charitable Grant (Professor Robin Murray). ARTK is funded by an NIHR Maudsley Biomedical Research Centre studentship. The authors also acknowledge use of the research computing facility at King{\textquoteright}s College London, Rosalind ( https://rosalind.kcl.ac.uk ), which was part-funded by capital equipment grants from Guy{\textquoteright}s and St Thomas{\textquoteright} Charity (TR130505) and Maudsley Charity (award 980). Funding Information: We thank all GLAD Study volunteers for their participation, and gratefully acknowledge the National Institute for Health and Care Research (NIHR) BioResource, NIHR BioResource centres, NHS Trusts and staff for their contribution. We also acknowledge King{\textquoteright}s College London, South London and Maudsley NHS Trust and King{\textquoteright}s Health Partners. We thank the National Institute for Health and Care Research, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s12888-022-04275-6",

language = "English",

volume = "22",

journal = "BMC Psychiatry",

issn = "1471-244X",

publisher = "BioMed Central Ltd",

}

Rayner, C, Coleman, JRI, Skelton, M, Armour, C, Bradley, J, Buckman, JEJ, Davies, MR, Hirsch, CR, Hotopf, M, Hübel, C, Jones, IR, Kalsi, G, Kingston, N, Krebs, G, Lin, Y, Monssen, D, McIntosh, AM, Mundy, JR, Peel, AJ, Rimes, KA, Rogers, HC, Smith, DJ, ter Kuile, AR, Thompson, KN, Veale, D, Wingrove, J, Walters, JTR, Breen, G & Eley, TC 2022, 'Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants', BMC Psychiatry, vol. 22, 719. https://doi.org/10.1186/s12888-022-04275-6

Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants. / Rayner, Christopher; Coleman, Jonathan R.I.; Skelton, Megan et al.
In: BMC Psychiatry, Vol. 22, 719, 12.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants

AU - Rayner, Christopher

AU - Coleman, Jonathan R.I.

AU - Skelton, Megan

AU - Armour, Cherie

AU - Bradley, John

AU - Buckman, Joshua E.J.

AU - Davies, Molly R.

AU - Hirsch, Colette R.

AU - Hotopf, Matthew

AU - Hübel, Christopher

AU - Jones, Ian R.

AU - Kalsi, Gursharan

AU - Kingston, Nathalie

AU - Krebs, Georgina

AU - Lin, Yuhao

AU - Monssen, Dina

AU - McIntosh, Andrew M.

AU - Mundy, Jessica R.

AU - Peel, Alicia J.

AU - Rimes, Katharine A.

AU - Rogers, Henry C.

AU - Smith, Daniel J.

AU - ter Kuile, Abigail R.

AU - Thompson, Katherine N.

AU - Veale, David

AU - Wingrove, Janet

AU - Walters, James T.R.

AU - Breen, Gerome

AU - Eley, Thalia C.

N1 - Funding Information: TCE and GB are part-funded by a program grant from the UK Medical Research Council (MR/V012878/1). CR is supported by a grant from Fondation Peters to TCE and GB. AJP is supported by an ESRC studentship. GK is funded by an MRC Clinical Research Training Fellowship (MR/N001400/1). MS is funded by an NIHR Maudsley Biomedical Research Centre studentship. CH acknowledges funding from Lundbeckfonden (R276-2018-4581). JB was funded on a clinical research fellowship from the Wellcome Trust (201292/Z/16/Z). JM is funded by the NIHR Maudsley Biomedical Research Centre and the Lord Leverhulme Charitable Grant (Professor Robin Murray). ARTK is funded by an NIHR Maudsley Biomedical Research Centre studentship. The authors also acknowledge use of the research computing facility at King’s College London, Rosalind ( https://rosalind.kcl.ac.uk ), which was part-funded by capital equipment grants from Guy’s and St Thomas’ Charity (TR130505) and Maudsley Charity (award 980). Funding Information: We thank all GLAD Study volunteers for their participation, and gratefully acknowledge the National Institute for Health and Care Research (NIHR) BioResource, NIHR BioResource centres, NHS Trusts and staff for their contribution. We also acknowledge King’s College London, South London and Maudsley NHS Trust and King’s Health Partners. We thank the National Institute for Health and Care Research, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - BACKGROUND: Progress towards stratified care for anxiety and depression will require the identification of new predictors. We collected data on retrospectively self-reported therapeutic outcomes in adults who received psychological therapy in the UK in the past ten years. We aimed to replicate factors associated with traditional treatment outcome measures from the literature.METHODS: Participants were from the Genetic Links to Anxiety and Depression (GLAD) Study, a UK-based volunteer cohort study. We investigated associations between retrospectively self-reported outcomes following therapy, on a five-point scale (global rating of change; GRC) and a range of sociodemographic, clinical and therapy-related factors, using ordinal logistic regression models (n = 2890).RESULTS: Four factors were associated with therapy outcomes (adjusted odds ratios, OR). One sociodemographic factor, having university-level education, was associated with favourable outcomes (OR = 1.37, 95%CI: 1.18, 1.59). Two clinical factors, greater number of reported episodes of illness (OR = 0.95, 95%CI: 0.92, 0.97) and higher levels of personality disorder symptoms (OR = 0.89, 95%CI: 0.87, 0.91), were associated with less favourable outcomes. Finally, reported regular use of additional therapeutic activities was associated with favourable outcomes (OR = 1.39, 95%CI: 1.19, 1.63). There were no statistically significant differences between fully adjusted multivariable and unadjusted univariable odds ratios.CONCLUSION: Therapy outcome data can be collected quickly and inexpensively using retrospectively self-reported measures in large observational cohorts. Retrospectively self-reported therapy outcomes were associated with four factors previously reported in the literature. Similar data collected in larger observational cohorts may enable detection of novel associations with therapy outcomes, to generate new hypotheses, which can be followed up in prospective studies.

AB - BACKGROUND: Progress towards stratified care for anxiety and depression will require the identification of new predictors. We collected data on retrospectively self-reported therapeutic outcomes in adults who received psychological therapy in the UK in the past ten years. We aimed to replicate factors associated with traditional treatment outcome measures from the literature.METHODS: Participants were from the Genetic Links to Anxiety and Depression (GLAD) Study, a UK-based volunteer cohort study. We investigated associations between retrospectively self-reported outcomes following therapy, on a five-point scale (global rating of change; GRC) and a range of sociodemographic, clinical and therapy-related factors, using ordinal logistic regression models (n = 2890).RESULTS: Four factors were associated with therapy outcomes (adjusted odds ratios, OR). One sociodemographic factor, having university-level education, was associated with favourable outcomes (OR = 1.37, 95%CI: 1.18, 1.59). Two clinical factors, greater number of reported episodes of illness (OR = 0.95, 95%CI: 0.92, 0.97) and higher levels of personality disorder symptoms (OR = 0.89, 95%CI: 0.87, 0.91), were associated with less favourable outcomes. Finally, reported regular use of additional therapeutic activities was associated with favourable outcomes (OR = 1.39, 95%CI: 1.19, 1.63). There were no statistically significant differences between fully adjusted multivariable and unadjusted univariable odds ratios.CONCLUSION: Therapy outcome data can be collected quickly and inexpensively using retrospectively self-reported measures in large observational cohorts. Retrospectively self-reported therapy outcomes were associated with four factors previously reported in the literature. Similar data collected in larger observational cohorts may enable detection of novel associations with therapy outcomes, to generate new hypotheses, which can be followed up in prospective studies.

KW - Cognitive behavioral therapy

KW - Counselling

KW - Minimal phenotyping

U2 - 10.1186/s12888-022-04275-6

DO - 10.1186/s12888-022-04275-6

M3 - Article

C2 - 36401199

SN - 1471-244X

VL - 22

JO - BMC Psychiatry

JF - BMC Psychiatry

M1 - 719

ER -

Patient characteristics associated with retrospectively self-reported treatment outcomes following psychological therapy for anxiety or depressive disorders - a cohort of GLAD study participants

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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