Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration

S. Farrell, Brian McMaster, David Gibson, Michael Shields, W.A. McCallion

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Gastro-oesophageal reflux (GOR)-related aspiration is associated with respiratory disease, but the current "gold standard" investigation, the lipid-laden macrophage index (LLMI), is flawed. A specific marker of GOR-related aspiration should originate in the stomach, but not the lung. An assay to detect gastric pepsin in the bronchoalveolar lavage (BAL) of children was developed and validated.
Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalJournal of Pediatric Surgery
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 2006
Event52nd Annual Congress of British-Association-of-Paediatric-Surgeons - Dublin, Ireland
Duration: 01 Jul 200601 Jul 2006

ASJC Scopus subject areas

  • Surgery

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