Gastro-oesophageal reflux (GOR)-related aspiration is associated with respiratory disease, but the current "gold standard" investigation, the lipid-laden macrophage index (LLMI), is flawed. A specific marker of GOR-related aspiration should originate in the stomach, but not the lung. An assay to detect gastric pepsin in the bronchoalveolar lavage (BAL) of children was developed and validated.
|Number of pages||5|
|Journal||Journal of Pediatric Surgery|
|Publication status||Published - Feb 2006|
|Event||52nd Annual Congress of British-Association-of-Paediatric-Surgeons - Dublin, Ireland|
Duration: 01 Jul 2006 → 01 Jul 2006
ASJC Scopus subject areas
Farrell, S., McMaster, B., Gibson, D., Shields, M., & McCallion, W. A. (2006). Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration. Journal of Pediatric Surgery, 41(2), 289-293. https://doi.org/10.1016/j.jpedsurg.2005.11.002