Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery

John G. Hardy; Megan N. Amend; Sydney Geissler; Vincent M. Lynch; Christine E. Schmidt

doi:10.1039/C5TB00106D

Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery

John G. Hardy, Megan N. Amend, Sydney Geissler, Vincent M. Lynch, Christine E. Schmidt

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

240 Downloads (Pure)

Abstract

We report the preparation and characterization of films of electroactive supramolecular polymers based on non-electroactive oligoalanines and electroactive oligoanilines. Fibroblasts adhered to and proliferated on the films, and the delivery of the clinically relevant anti-inflammatory drug dexamethasone phosphate could be enhanced upon the application of an electrical stimulus.

Original language	English
Pages (from-to)	5005-5009
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	25
Early online date	08 Jun 2015
DOIs	https://doi.org/10.1039/C5TB00106D
Publication status	Published - 2015
Externally published	Yes

Keywords

SUPRAMOLECULAR CHEMISTRY
SUPRAMOLECULAR POLYMERS
BIOMATERIALS
Drug delivery

ASJC Scopus subject areas

Chemistry (miscellaneous)
Biomaterials

Access to Document

10.1039/C5TB00106D

Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine-oligoaniline-oligoalanine) for electrochemically enhanced drug delivery
©2015 The Royal Society of Chemistry
Accepted author manuscript, 292 KB

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Hardy, J. G., Amend, M. N., Geissler, S., Lynch, V. M., & Schmidt, C. E. (2015). Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery. Journal of Materials Chemistry B, 3(25), 5005-5009. https://doi.org/10.1039/C5TB00106D

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abstract = "We report the preparation and characterization of films of electroactive supramolecular polymers based on non-electroactive oligoalanines and electroactive oligoanilines. Fibroblasts adhered to and proliferated on the films, and the delivery of the clinically relevant anti-inflammatory drug dexamethasone phosphate could be enhanced upon the application of an electrical stimulus.",

keywords = "SUPRAMOLECULAR CHEMISTRY, SUPRAMOLECULAR POLYMERS, BIOMATERIALS, Drug delivery",

author = "Hardy, {John G.} and Amend, {Megan N.} and Sydney Geissler and Lynch, {Vincent M.} and Schmidt, {Christine E.}",

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language = "English",

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Hardy, JG, Amend, MN, Geissler, S, Lynch, VM & Schmidt, CE 2015, 'Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery', Journal of Materials Chemistry B, vol. 3, no. 25, pp. 5005-5009. https://doi.org/10.1039/C5TB00106D

Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery. / Hardy, John G.; Amend, Megan N.; Geissler, Sydney et al.
In: Journal of Materials Chemistry B, Vol. 3, No. 25, 2015, p. 5005-5009.

Research output: Contribution to journal › Article › peer-review

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T1 - Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery

AU - Hardy, John G.

AU - Amend, Megan N.

AU - Geissler, Sydney

AU - Lynch, Vincent M.

AU - Schmidt, Christine E.

PY - 2015

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AB - We report the preparation and characterization of films of electroactive supramolecular polymers based on non-electroactive oligoalanines and electroactive oligoanilines. Fibroblasts adhered to and proliferated on the films, and the delivery of the clinically relevant anti-inflammatory drug dexamethasone phosphate could be enhanced upon the application of an electrical stimulus.

KW - SUPRAMOLECULAR CHEMISTRY

KW - SUPRAMOLECULAR POLYMERS

KW - BIOMATERIALS

KW - Drug delivery

U2 - 10.1039/C5TB00106D

DO - 10.1039/C5TB00106D

M3 - Article

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SP - 5005

EP - 5009

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Hardy JG, Amend MN, Geissler S, Lynch VM, Schmidt CE. Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery. Journal of Materials Chemistry B. 2015;3(25):5005-5009. Epub 2015 Jun 8. doi: 10.1039/C5TB00106D