Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe,

Jamie Toole, Hannah L. Bolt, John J. Marley, Sheila Patrick, Steven L. Cobb*, Fionnuala T. Lundy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Downloads (Pure)

Abstract

Peptoids (oligo -substituted glycines) are peptide analogues, which can be designed to mimic host antimicrobial peptides, with the advantage that they are resistant to proteolytic degradation. Few studies on the antimicrobial efficacy of peptoids have focused on Gram negative anaerobic microbes associated with clinical infections, which are commonly recalcitrant to antibiotic treatment. We therefore studied the cytotoxicity and antibiofilm activity of a family of peptoids against the Gram negative obligate anaerobe , which is associated with infections in the oral cavity. Two peptoids, peptoid (NaeNpheNphe)4 and peptoid (NahNspeNspe) were shown to be efficacious against biofilms at a concentration of 1 μM. At this concentration, peptoids and were not cytotoxic to human erythrocytes or primary human gingival fibroblast cells. Peptoids and therefore have merit as future therapeutics for the treatment of oral infections.
Original languageEnglish
Article numbere4741
Number of pages10
JournalMolecules
Volume26
Issue number16
Early online date05 Aug 2021
DOIs
Publication statusEarly online date - 05 Aug 2021

Keywords

  • antimicrobial
  • biofilms
  • cytotoxicity
  • peptidomimetic
  • peptoid
  • targeted therapeutic

Fingerprint

Dive into the research topics of 'Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe,'. Together they form a unique fingerprint.

Cite this