Performance Evaluation of Bioresorbable Polymers used in Bone Fixation and Tissue Scaffolds: Invited Speaker

Research output: Contribution to conferenceAbstract

Abstract

Implants made from bioresorbable polymers are gaining significant interest in orthopaedic, sports-injury and cardiovascular markets. The advantage of such materials over permanent metallic implants is that they provide temporary support during healing, then gradually degrade, transferring mechanical loads to regenerating tissue. They are also utilised in drug and bioactive release systems owing to the ability to tailor their bioresorption rate via appropriate polymer selection and post-processing procedures. Furthermore they have potential for application in patient-specific tissue scaffolds produced by layer-by-layer manufacturing techniques such as fused deposition modelling.

This presentation will review manufacturing considerations for the fabrication of bioresorbable implants, focusing on melt-processing and tissue scaffold production via fused deposition modelling. The polymers of focus will be poly lactic acid (PLA) and poly lactic-co-glycolic acid (PLGA). Furthermore post-process sterilisation strategies will be appraised with the aim of quantifying the effects of such processes and assessing the implications for performance. Typical degradation and bioactive release mechanisms will be evaluated for clinically relevant bioresorbable polymers containing bioactive fillers such as calcium carbonate, calcium phosphate and silver nanoparticles. The ability to control release profiles will be demonstrated via the application of low energy electron beam irradiation to modify the polymer’s degradation profile. Finally the benefits of in vitro degradation testing will be considered along with some of the challenges of evaluating degradable systems in vivo.
Original languageEnglish
Publication statusPublished - 26 Apr 2017
Event3rd International Symposium on Biomaterials and Biosensors - Fetheye, Turkey
Duration: 22 Apr 201726 Apr 2017
https://www.nature.com/natureevents/science/events/49639-3rd_International_Symposium_on_Biomaterials_Biosensors

Conference

Conference3rd International Symposium on Biomaterials and Biosensors
Abbreviated titleBIOMATSEN 2017
CountryTurkey
CityFetheye
Period22/04/201726/04/2017
Internet address

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    Buchanan, F. (2017). Performance Evaluation of Bioresorbable Polymers used in Bone Fixation and Tissue Scaffolds: Invited Speaker. Abstract from 3rd International Symposium on Biomaterials and Biosensors, Fetheye, Turkey.