Periodontitis and Incident Type 2 Diabetes: a prospective cohort study

Lewis Winning; Christopher C Patterson; Charlotte E Neville; Frank Kee; Gerard J Linden

doi:10.1111/jcpe.12691

Periodontitis and Incident Type 2 Diabetes: a prospective cohort study

Lewis Winning, Christopher C Patterson, Charlotte E Neville, Frank Kee, Gerard J Linden

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Abstract

OBJECTIVES: To investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years.

METHODS: 1331 dentate, diabetes-free males in Northern Ireland underwent a detailed periodontal examination during 2001-2003. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date. Cox's proportional hazard models were used to estimate the effect of periodontitis on incident diabetes. Multivariable analysis included adjustment for various known confounders.

RESULTS: The mean age of the men was 63.7 (SD 3.0) years. There were 80 cases (6.0%) of incident T2DM. Follow-up was for a median period of 7.8 years (IQR 6.7-8.3). After adjusting for confounding variables, the hazard ratio (HR) for incident T2DM in men with moderate / severe periodontitis versus those with no / mild periodontitis was 1.69 (95% CI 1.06-2.69), p=0.03.

CONCLUSION: There was evidence in this homogenous group of dentate men, that those with moderate to severe periodontitis had a significantly increased risk of incident T2DM.

Original language	English
Pages (from-to)	266-274
Number of pages	9
Journal	Journal of Clinical Periodontology
Volume	44
Issue number	3
Early online date	30 Dec 2016
DOIs	https://doi.org/10.1111/jcpe.12691
Publication status	Published - 01 Mar 2017

Bibliographical note

Publisher Copyright:
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

incident diabetes
inflammation
periodontitis

ASJC Scopus subject areas

Periodontics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jcpe.12691Licence: Unspecified

Periodontitis and Incident Type 2 Diabetes: a prospective cohort study
Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved. This is the peer reviewed version of the following article, which has been published in final form at http://onlinelibrary.wiley.com/wol1/doi/10.1111/jcpe.12691/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Accepted author manuscript, 489 KBLicence: Unspecified

The osteogenic potential of periodontal ligament stem cells
Winning, L. (Author), Lundy, F. (Supervisor), 2018
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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title = "Periodontitis and Incident Type 2 Diabetes: a prospective cohort study",

abstract = "OBJECTIVES: To investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years.METHODS: 1331 dentate, diabetes-free males in Northern Ireland underwent a detailed periodontal examination during 2001-2003. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date. Cox's proportional hazard models were used to estimate the effect of periodontitis on incident diabetes. Multivariable analysis included adjustment for various known confounders.RESULTS: The mean age of the men was 63.7 (SD 3.0) years. There were 80 cases (6.0\%) of incident T2DM. Follow-up was for a median period of 7.8 years (IQR 6.7-8.3). After adjusting for confounding variables, the hazard ratio (HR) for incident T2DM in men with moderate / severe periodontitis versus those with no / mild periodontitis was 1.69 (95\% CI 1.06-2.69), p=0.03.CONCLUSION: There was evidence in this homogenous group of dentate men, that those with moderate to severe periodontitis had a significantly increased risk of incident T2DM. ",

keywords = "incident diabetes, inflammation, periodontitis",

author = "Lewis Winning and Patterson, \{Christopher C\} and Neville, \{Charlotte E\} and Frank Kee and Linden, \{Gerard J\}",

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doi = "10.1111/jcpe.12691",

language = "English",

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AU - Winning, Lewis

AU - Patterson, Christopher C

AU - Neville, Charlotte E

AU - Kee, Frank

AU - Linden, Gerard J

PY - 2017/3/1

Y1 - 2017/3/1

N2 - OBJECTIVES: To investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years.METHODS: 1331 dentate, diabetes-free males in Northern Ireland underwent a detailed periodontal examination during 2001-2003. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date. Cox's proportional hazard models were used to estimate the effect of periodontitis on incident diabetes. Multivariable analysis included adjustment for various known confounders.RESULTS: The mean age of the men was 63.7 (SD 3.0) years. There were 80 cases (6.0%) of incident T2DM. Follow-up was for a median period of 7.8 years (IQR 6.7-8.3). After adjusting for confounding variables, the hazard ratio (HR) for incident T2DM in men with moderate / severe periodontitis versus those with no / mild periodontitis was 1.69 (95% CI 1.06-2.69), p=0.03.CONCLUSION: There was evidence in this homogenous group of dentate men, that those with moderate to severe periodontitis had a significantly increased risk of incident T2DM.

AB - OBJECTIVES: To investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years.METHODS: 1331 dentate, diabetes-free males in Northern Ireland underwent a detailed periodontal examination during 2001-2003. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date. Cox's proportional hazard models were used to estimate the effect of periodontitis on incident diabetes. Multivariable analysis included adjustment for various known confounders.RESULTS: The mean age of the men was 63.7 (SD 3.0) years. There were 80 cases (6.0%) of incident T2DM. Follow-up was for a median period of 7.8 years (IQR 6.7-8.3). After adjusting for confounding variables, the hazard ratio (HR) for incident T2DM in men with moderate / severe periodontitis versus those with no / mild periodontitis was 1.69 (95% CI 1.06-2.69), p=0.03.CONCLUSION: There was evidence in this homogenous group of dentate men, that those with moderate to severe periodontitis had a significantly increased risk of incident T2DM.

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KW - inflammation

KW - periodontitis

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DO - 10.1111/jcpe.12691

M3 - Article

C2 - 28036104

SN - 0303-6979

VL - 44

SP - 266

EP - 274

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

IS - 3

ER -

Periodontitis and Incident Type 2 Diabetes: a prospective cohort study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Student theses

The osteogenic potential of periodontal ligament stem cells

Cite this