Periodontitis and Systemic Disease: Association or Causality?

Lewis Winning, Gerard Linden

Research output: Contribution to journalArticlepeer-review

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Purpose of Review The aim was to assess recent evidence that diabetes, metabolic syndrome (MetS) and obesity impact the progression of periodontitis. Recent Findings Electronic searches using Embase, Medline, and Web of Science were carried out for epidemiological studies on humans, published between 2014 and 2016. A small number of prospective studies and systematic reviews were identified that in general provide further support for the hypothesis that diabetes, metabolic syndrome and obesity can adversely affect the periodontal condition. Summary Confounding remains the most challenging issue in the interpretation of the associations found between diabetes, MetS, obesity and periodontal disease. Recent research applying a Mendelian randomisation approach concluded that the association between obesity and periodontitisis confounded and questioned a role for obesity in causation. Further studies are warranted to assess the issue of causality.
Original languageEnglish
Number of pages7
JournalCurrent Oral Health Reports
Publication statusPublished - 23 Jan 2017

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