Peroxiredoxin: a central player in immune modulation: a central player in immune modulation

M W Robinson, A T Hutchinson, J P Dalton, S Donnelly

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.
Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalParasite Immunology
Volume32
Issue number5
DOIs
Publication statusPublished - May 2010

ASJC Scopus subject areas

  • Immunology
  • Parasitology

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