Peroxiredoxin: a central player in immune modulation: a central player in immune modulation

M W Robinson; A T Hutchinson; J P Dalton; S Donnelly

doi:10.1111/j.1365-3024.2010.01201.x

Peroxiredoxin: a central player in immune modulation: a central player in immune modulation

M W Robinson, A T Hutchinson, J P Dalton, S Donnelly

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.

Original language	English
Pages (from-to)	305-313
Number of pages	9
Journal	Parasite Immunology
Volume	32
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-3024.2010.01201.x
Publication status	Published - May 2010

ASJC Scopus subject areas

Immunology
Parasitology

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abstract = "Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.",

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AB - Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.

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DO - 10.1111/j.1365-3024.2010.01201.x

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