Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children

Christopher A Moxon, Ngawina V Chisala, Samuel C Wassmer, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, Brian Faragher, Neil Kennedy, Cheng-Hock Toh, Alister G Craig, Robert S Heyderman

Research output: Contribution to journalArticle

31 Citations (Scopus)
176 Downloads (Pure)

Abstract

Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalThe Journal of Infectious Diseases
Volume209
Issue number4
Early online date17 Sep 2013
DOIs
Publication statusPublished - 2014

Keywords

  • Analysis of Variance
  • Biomarkers
  • C-Reactive Protein
  • Case-Control Studies
  • Child, Preschool
  • Endothelium
  • Female
  • Fever
  • Humans
  • Inflammation
  • Intercellular Adhesion Molecule-1
  • Malaria, Cerebral
  • Malaria, Falciparum
  • Malawi
  • Male
  • Vesicular Transport Proteins

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