Projects per year
Abstract
Chronic cough can be a troublesome clinical problem. Current thinking is that increased activity and/or enhanced sensitivity of the peripheral and central neural pathways mediates chronic cough via processes similar to those associated with the development of chronic pain. While inflammation is widely thought to be involved in the development of chronic cough, the true mechanisms causing altered neural activity and sensitisation remain largely unknown. In this back-to-basic perspective article we explore evidence that inflammation in chronic cough may, at least in part, involve neuroinflammation orchestrated by glial cells of the nervous system. We summarise the extensive evidence for the role of both peripheral and central glial cells in chronic pain and hypothesise that the commonalities between the pain and cough pathogenesis and clinical presentation warrant investigations into the neuroinflammatory mechanisms that contribute to chronic cough. We open the debate that glial cells may represent an underappreciated therapeutic target for controlling troublesome cough in disease.
Original language | English |
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Article number | 2000758 |
Number of pages | 10 |
Journal | European Respiratory Journal |
Volume | 56 |
Early online date | 09 Jul 2020 |
DOIs | |
Publication status | Published - 22 Oct 2020 |
Keywords
- chronic cough
- neuroinflammation
- glial cells
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Dive into the research topics of 'Perspectives on neuroinflammation contributing to chronic cough'. Together they form a unique fingerprint.Projects
- 1 Active
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R6964PMY: Interreg VA: BREATH - Border and REgions Airways Training Hub (Full Proposal)
Martin, L., Lundy, F., McGarvey, L. & Tikhonova, I.
02/05/2017 → …
Project: Research
Prizes
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Vice-Chancellor's Research Culture Prize 2020
Martin, Lorraine (Recipient), Lundy, Fionnuala (Recipient) & McGarvey, Lorcan (Recipient), 17 Dec 2020
Prize: Prize (including medals and awards)
Press / Media
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QUEEN'S SECURES EU FUNDING FOR FIGHT AGAINST LUNG DISEASE
Lorraine Martin, Lorcan McGarvey & Fionnuala Lundy
26/01/2017
1 Media contribution
Press/Media: Research