pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization

Jiong Zou, Goran Jafr, Efrosyni Themistou, Yoonsing Yap, Zachary A. P. Wintrob, Paschalis Alexandridis, Alice C. Ceacareanu, Chong Cheng

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.
Original languageEnglish
Pages (from-to)4493-4495
JournalChemical Communications
Volume47
Issue number15
Early online date26 Sep 2011
DOIs
Publication statusPublished - 2011

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