Pharmacological evaluation of Rhazya stricta root extract

Rashid Mahmood*, Farnaz Malik, Shazia Shamas, Tanveer Ahmed, Mehran Kausar, Samina Rubnawaz, Muhammad Ashfaq, Shahzad Hussain, Brian Desmond Green, Bushra Mirza

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
9 Downloads (Pure)


The present study aimed to screen the Rhazya stricta Decne root for its antihyperglycemic and antioxidants potential through in-vitro assays along with phytochemical and elemental analyses. The crude extract was prepared through maceration and fractionated using solvent-solvent extraction technique. The spectroscopic studies indicated the presence of various phytochemical classes in the extract and its fractions. The antioxidant assays showed notable results along with a good concentration of phenolic and flavonoid contents. Enzyme inhibition assays demonstrated glucose-lowering effects by inhibiting the enzyme activity which could reduce post-prandial blood glucose level. The Dipeptidyl peptidase-IV (DPP-IV) inhibition assay results showed the novel DPP-IV inhibition activity of the plant extract and all fractions showed noteworthy enzyme inhibition and antihyperglycemic activity. Conclusively, the Rhazya stricta root extract displayed its antioxidant and antihyperglycemic potential due to the presence of various classes of phytochemicals and micro-nutrients.

Original languageEnglish
Pages (from-to)188-206
Number of pages19
JournalBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Issue number2
Publication statusPublished - 30 Mar 2020


  • Antidiabetic
  • Antioxidant
  • DPP-IV inhibitor
  • Phytochemical
  • Rhazya stricta
  • Spectroscopic studies

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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