Phase Behavior of Reverse Poloxamers and Poloxamines in Water

Eneko Larrañeta, Jose Ramon Isasi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The phase behavior of two types of poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) copolymers in aqueous solutions was studied by light scattering, viscometry, and infrared spectroscopy. Both the reverse poloxamer (Pluronic 10R5) and the star type poloxamine (Tetronic 90R4) have practically the same PEO/PPO ratio with their hydrophobic blocks (PPO) located in the outer part. The temperature-composition phase diagrams show that both 10R5 and 90R4 tend to form aggregates in water. Up to four different phases can be detected in the case of Tetronic 90R4 for each temperature: unimers, random networks, micellar networks, and macrophase separation. Viscometric and infrared measurements complemented the results obtained by light scattering and visual inspection.

Original languageEnglish
Pages (from-to)1045-1053
Number of pages9
JournalLangmuir
Volume29
Issue number4
DOIs
Publication statusPublished - 29 Jan 2013

Keywords

  • OXIDE) TRIBLOCK COPOLYMERS
  • AQUEOUS-SOLUTIONS
  • POLY(ETHYLENE OXIDE)
  • BLOCK-COPOLYMER
  • MICELLE FORMATION
  • ASSOCIATIVE BEHAVIOR
  • FTIR SPECTROSCOPY
  • SALT-SOLUTION
  • MICELLIZATION
  • SCATTERING

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