Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity

Jean Marie Lehn (Inventor), Yves Claude Nicolau (Inventor), Srinivasu Pothukanuri (Inventor), Adam Brockman (Inventor), John Hey (Inventor), Yongxin Jeremy Yu (Inventor)

Research output: Patent


The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.
Original languageEnglish
Patent numberUS20140142052 A1
IPCA61K31/7028, C07F9/6564, A61K31/6615, A61K45/06
Publication statusPublished - May 2014


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