Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity

Jean Marie Lehn (Inventor), Yves Claude Nicolau (Inventor), Srinivasu Pothukanuri (Inventor), Adam Brockman (Inventor), John Hey (Inventor), Yongxin Jeremy Yu (Inventor)

Research output: Patent

Abstract

The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.
Original languageEnglish
Patent numberUS20140142052 A1
IPCA61K31/7028, C07F9/6564, A61K31/6615, A61K45/06
Publication statusPublished - May 2014

Fingerprint

Diphosphates
Patents and inventions
Bioactivity
Derivatives
Chemical analysis
Hemoglobins
Phosphotransferases
Pharmaceutical Preparations
polyol
diphosphoric acid

Cite this

Lehn, J. M., Nicolau, Y. C., Pothukanuri, S., Brockman, A., Hey, J., & Yu, Y. J. (2014). IPC No. A61K31/7028, C07F9/6564, A61K31/6615, A61K45/06. Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity. (Patent No. US20140142052 A1).
Lehn, Jean Marie (Inventor) ; Nicolau, Yves Claude (Inventor) ; Pothukanuri, Srinivasu (Inventor) ; Brockman, Adam (Inventor) ; Hey, John (Inventor) ; Yu, Yongxin Jeremy (Inventor). / Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity. IPC No.: A61K31/7028, C07F9/6564, A61K31/6615, A61K45/06. Patent No.: US20140142052 A1.
@misc{dedd0cfc46c34053b2249513cefc756b,
title = "Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity",
abstract = "The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.",
author = "Lehn, {Jean Marie} and Nicolau, {Yves Claude} and Srinivasu Pothukanuri and Adam Brockman and John Hey and Yu, {Yongxin Jeremy}",
year = "2014",
month = "5",
language = "English",
type = "Patent",
note = "US20140142052 A1; A61K31/7028, C07F9/6564, A61K31/6615, A61K45/06",

}

Lehn, JM, Nicolau, YC, Pothukanuri, S, Brockman, A, Hey, J & Yu, YJ 2014, Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity, Patent No. US20140142052 A1, IPC No. A61K31/7028, C07F9/6564, A61K31/6615, A61K45/06.

Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity. / Lehn, Jean Marie (Inventor); Nicolau, Yves Claude (Inventor); Pothukanuri, Srinivasu (Inventor); Brockman, Adam (Inventor); Hey, John (Inventor); Yu, Yongxin Jeremy (Inventor).

IPC No.: A61K31/7028, C07F9/6564, A61K31/6615, A61K45/06. Patent No.: US20140142052 A1.

Research output: Patent

TY - PAT

T1 - Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity

AU - Lehn, Jean Marie

AU - Nicolau, Yves Claude

AU - Pothukanuri, Srinivasu

AU - Brockman, Adam

AU - Hey, John

AU - Yu, Yongxin Jeremy

PY - 2014/5

Y1 - 2014/5

N2 - The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.

AB - The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.

M3 - Patent

M1 - US20140142052 A1

ER -

Lehn JM, Nicolau YC, Pothukanuri S, Brockman A, Hey J, Yu YJ, inventors. Phosphorylated polyols, pyrophosphates, and derivatives thereof having biological activity. A61K31/7028, C07F9/6564, A61K31/6615, A61K45/06. 2014 May.