Photochemically controlled drug dosing from a polymeric scaffold

Louise Donnelly, John G. Hardy, Sean P. Gorman, David S. Jones, Nicola J. Irwin, Colin P. McCoy

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Abstract

Purpose To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2- methyoxyethyl acrylate) (pMEA) scaffold.

Methods Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spec- troscopy and mass spectrometry following chromatographic purification. Conjugate photolysis was investigated in acetonitrile solution and within the pMEA matrix following exposure to low-power 365 nm irradiation. Photo-liberation of drug from pMEA into phosphate buffered saline was monitored using UV-vis spectroscopy.

Results The synthetic procedures yielded the desired drug conjugates with full supporting characterisation. Drug regen- eration through photolysis of the synthesised conjugates was suc- cessful in both acetonitrile solution and within the pMEA scaffold upon UV irradiation. Conjugates were retained within the pMEA scaffold with exclusive drug liberation following irradia- tion and increased drug dose with increasing exposure. Multi- dosing capacity was demonstrated though the ability of successive irradiation periods to generate further bursts of drug.

Conclusion This study demonstrates the first application of photochemically controlled drug release from a biomaterial coating and the feasibility of using pMEA as a scaffold for housing the photoactive drug-DMB conjugates.
Original languageEnglish
Number of pages8
JournalMolecular Pharmaceutics
Early online date15 May 2017
DOIs
Publication statusEarly online date - 15 May 2017

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