Photosensitisers - the progression from photodynamic therapy to anti-infective surfaces

Rebecca A. Craig, Colin P. McCoy*, Sean P. Gorman, David S. Jones

*Corresponding author for this work

Research output: Contribution to journalLiterature review

29 Citations (Scopus)
838 Downloads (Pure)

Abstract

Introduction: The application of light as a stimulus in pharmaceutical systems and the associated ability to provide precise spatiotemporal control over location, wavelength and intensity, allowing ease of external control independent of environmental conditionals, has led to its increased use. Of particular note is the use of light with photosensitisers.

Areas covered: Photosensitisers are widely used in photodynamic therapy to cause a cidal effect towards cells on irradiation due to the generation of reactive oxygen species. These cidal effects have also been used to treat infectious diseases. The effects and benefits of photosensitisers in the treatment of such conditions are still being developed and further realised, with the design of novel delivery strategies. This review provides an overview of the realisation of the pharmaceutically relevant uses of photosensitisers, both in the context of current research and in terms of current clinical application, and looks to the future direction of research.

Expert opinion: Substantial advances have been and are being made in the use of photosensitisers. Of particular note are their antimicrobial applications, due to absence of resistance that is so frequently associated with conventional treatments. Their potency of action and the ability to immobilise to polymeric supports is opening a wide range of possibilities with great potential for use in healthcare infection prevention strategies.
Original languageEnglish
Pages (from-to)85-101
Number of pages17
JournalExpert Opinion on Drug Delivery
Volume12
Issue number1
Early online date23 Sep 2014
DOIs
Publication statusPublished - Jan 2015

Keywords

  • antimicrobial
  • photodynamic therapy
  • photosensitiser
  • reactive oxygen species
  • surfaces
  • RANDOMIZED CLINICAL-TRIAL
  • PORPHYRIN-CELLULOSE NANOCRYSTALS
  • ANTIMICROBIAL CHEMOTHERAPY PACT
  • INTRAOCULAR-LENS BIOMATERIALS
  • DELTA-AMINOLEVULINIC-ACID
  • FACIAL ACNE-VULGARIS
  • CUTANEOUS LEISHMANIASIS
  • 5-AMINOLEVULINIC ACID
  • NONSURGICAL TREATMENT
  • METHYLENE-BLUE

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