Abstract
Background: Few observational studies have assessed the role of physical activity in oesophago-gastric cancer risk.
Objective: This prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer.
Methods: A cohort of 359,033 adults aged 40-69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between self-reported levels of physical activity and screen-based sedentary behaviour, and risk of oesophageal and gastric cancer were calculated using Cox proportional hazards models.
Results: During 8 years of follow-up (mean=5.5), 294 oesophageal cancer and 217 gastric cancer cases were identified. Physical activity and screen-based sedentary behaviour levels were not associated with overall oesophago-gastric cancer risk. However, when compared with low levels, high physical activity levels were associated with a significantly reduced risk of gastric non-cardia cancer (HR 0.58, 95% CI 0.37- 0.95). Moderate physical activity levels were associated with a 38% reduced risk of oesophageal adenocarcinoma (HR 0.62, 95% CI 0.43-0.89), although no doseresponse association was apparent.
Conclusion: Moderate, rather than high, physical activity levels were associated with the strongest reductions in oesophageal adenocarcinoma risk in this large UK prospective cohort.
Objective: This prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer.
Methods: A cohort of 359,033 adults aged 40-69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between self-reported levels of physical activity and screen-based sedentary behaviour, and risk of oesophageal and gastric cancer were calculated using Cox proportional hazards models.
Results: During 8 years of follow-up (mean=5.5), 294 oesophageal cancer and 217 gastric cancer cases were identified. Physical activity and screen-based sedentary behaviour levels were not associated with overall oesophago-gastric cancer risk. However, when compared with low levels, high physical activity levels were associated with a significantly reduced risk of gastric non-cardia cancer (HR 0.58, 95% CI 0.37- 0.95). Moderate physical activity levels were associated with a 38% reduced risk of oesophageal adenocarcinoma (HR 0.62, 95% CI 0.43-0.89), although no doseresponse association was apparent.
Conclusion: Moderate, rather than high, physical activity levels were associated with the strongest reductions in oesophageal adenocarcinoma risk in this large UK prospective cohort.
| Original language | English |
|---|---|
| Pages (from-to) | 1144-1154 |
| Journal | United European Gastroenterology Journal |
| Volume | 6 |
| Issue number | 8 |
| Early online date | 07 Jun 2018 |
| DOIs | |
| Publication status | Published - 01 Oct 2018 |
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- Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: a prospective cohort study within UK Biobank
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