Physical morbidity by surgical approach and tumor location in skull base surgery

John R de Almeida; Ian J Witterick; Patrick J Gullane; Fred Gentili; Lynne Lohfeld; Jolie Ringash; Achilles Thoma; Allan D Vescan

doi:10.1002/hed.23006

Physical morbidity by surgical approach and tumor location in skull base surgery

John R de Almeida, Ian J Witterick, Patrick J Gullane, Fred Gentili, Lynne Lohfeld, Jolie Ringash, Achilles Thoma, Allan D Vescan

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

ABSTRACT:

Background.Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach.

Methods.Skull base surgery patients (n¼138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development.

Results.Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%;p<.001). Those with central lesions presented with more neurologic (41.1% vs 12.3%;p<.001) and endocrine symptoms (19.2% vs 0%;p<.001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central)experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p¼.02) and endoscopic approaches (p¼.002) predicted increased nasal morbidity.

Conclusion.Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.

Original language	English
Pages (from-to)	493-9
Number of pages	7
Journal	Head & neck
Volume	35
Issue number	4
Early online date	11 May 2012
DOIs	https://doi.org/10.1002/hed.23006
Publication status	Published - Apr 2013
Externally published	Yes

Keywords

Adult
Aged
Endoscopy
Female
Humans
Male
Middle Aged
Morbidity
Neurosurgical Procedures
Postoperative Complications
Retrospective Studies
Skull Base
Skull Base Neoplasms
Journal Article
Research Support, Non-U.S. Gov't

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@article{c0314d29af7d47829fc4d29f4fca8b83,

title = "Physical morbidity by surgical approach and tumor location in skull base surgery",

abstract = "ABSTRACT:Background.Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach.Methods.Skull base surgery patients (n¼138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development.Results.Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%;p<.001). Those with central lesions presented with more neurologic (41.1% vs 12.3%;p<.001) and endocrine symptoms (19.2% vs 0%;p<.001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central)experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p¼.02) and endoscopic approaches (p¼.002) predicted increased nasal morbidity.Conclusion.Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.",

keywords = "Adult, Aged, Endoscopy, Female, Humans, Male, Middle Aged, Morbidity, Neurosurgical Procedures, Postoperative Complications, Retrospective Studies, Skull Base, Skull Base Neoplasms, Journal Article, Research Support, Non-U.S. Gov't",

author = "{de Almeida}, {John R} and Witterick, {Ian J} and Gullane, {Patrick J} and Fred Gentili and Lynne Lohfeld and Jolie Ringash and Achilles Thoma and Vescan, {Allan D}",

note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",

year = "2013",

month = apr,

doi = "10.1002/hed.23006",

language = "English",

volume = "35",

pages = "493--9",

journal = "Head & neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Physical morbidity by surgical approach and tumor location in skull base surgery

AU - de Almeida, John R

AU - Witterick, Ian J

AU - Gullane, Patrick J

AU - Gentili, Fred

AU - Lohfeld, Lynne

AU - Ringash, Jolie

AU - Thoma, Achilles

AU - Vescan, Allan D

PY - 2013/4

Y1 - 2013/4

N2 - ABSTRACT:Background.Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach.Methods.Skull base surgery patients (n¼138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development.Results.Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%;p<.001). Those with central lesions presented with more neurologic (41.1% vs 12.3%;p<.001) and endocrine symptoms (19.2% vs 0%;p<.001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central)experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p¼.02) and endoscopic approaches (p¼.002) predicted increased nasal morbidity.Conclusion.Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.

AB - ABSTRACT:Background.Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach.Methods.Skull base surgery patients (n¼138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development.Results.Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%;p<.001). Those with central lesions presented with more neurologic (41.1% vs 12.3%;p<.001) and endocrine symptoms (19.2% vs 0%;p<.001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central)experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p¼.02) and endoscopic approaches (p¼.002) predicted increased nasal morbidity.Conclusion.Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.

KW - Adult

KW - Aged

KW - Endoscopy

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Morbidity

KW - Neurosurgical Procedures

KW - Postoperative Complications

KW - Retrospective Studies

KW - Skull Base

KW - Skull Base Neoplasms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/hed.23006

DO - 10.1002/hed.23006

M3 - Article

C2 - 22581692

VL - 35

SP - 493

EP - 499

JO - Head & neck

JF - Head & neck

SN - 1043-3074

IS - 4

ER -

Physical morbidity by surgical approach and tumor location in skull base surgery

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Keywords

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