Physicochemical characterisation and drug release properties of celecoxib hot melt extruded glass solutions

Gavin Andrews, Osama Abu Diak, David Jones, Peter Hornsby, F. Kusmanto

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Formulation of Celecoxib into solid dosage forms is difficult due to the physical properties of the drug powder. However for the first time, this paper reports on the drug delivery characteristics glass solutions of celecoxib and polyvinylpyrrolidone prepared by hot melt extrusion, together with use of supercritical carbon dioxide to achieve a porous structure, in order to achieve a stable and enhanced drug release.
Original languageEnglish
Pages (from-to)1580-1590
Number of pages11
JournalJournal of Pharmacy and Pharmacology
Volume62
DOIs
Publication statusPublished - 2010

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