PKB binding proteins: Getting in on the akt

Derek Brazil, J. Park, B.A. Hemmings

Research output: Contribution to journalArticlepeer-review

449 Citations (Scopus)


Protein kinase B (PKB) has emerged as the focal point for many signal transduction pathways, regulating multiple cellular processes such as glucose metabolism, transcription, apoptosis, cell proliferation, angiogenesis, and cell motility. In addition to acting as a kinase toward many substrates involved in these processes, PKB forms complexes with other proteins that are not substrates, but rather act as modulators of PKB activity and function. In this review, we discuss the implications of these data in understanding the multitude of functions predicted for PKB in cells.
Original languageEnglish
Pages (from-to)293-303
Number of pages11
Issue number3
Publication statusPublished - 01 Nov 2002

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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