Abstract
Background
Plant-based diets have been associated with a lower risk of several chronic diseases, but the relationship with PD is unknown.
Objectives
We examined the association of three different plant-based diets with PD incidence in the UK Biobank cohort.
Methods
We conducted a prospective study among 126,283 participants from the UK Biobank cohort. Three plant-based diet indices (overall plant-based diet index, PDI; healthful plant-based diet index, hPDI; and unhealthful plant-based diet index, uPDI) were derived from 24-hour dietary recalls based on 17 food groups. Multivariable Cox regression models were used to estimate the risk of PD across quartiles of the PDIs and for each of the food groups that constituted the score. Further analyses were carried out to assess potential heterogeneity in associations between hPDI and PD across strata of some hypothesized effect modifiers.
Results
During 11.8 years of follow-up (1,490,139 person-years), 577 cases of PD incidence were reported. After multivariable adjustment, participants in the highest hPDI and overall PDI quartile had lower risk of PD (22% and 18%, respectively), whereas a higher uPDI was associated with a 38% higher PD risk. In food-based analyses, higher intakes of vegetables, nuts, and tea were associated with a lower risk of PD (28%, 31% and 25%, respectively). Stratifying by Polygenic Risk Score (PRS), results were significant only for those with a lower PRS for PD.
Conclusions
Following a healthful plant-based diet and in particular the inclusion of readily achievable intakes of vegetables, nuts and tea in the habitual diet are associated with a lower risk of PD.
Plant-based diets have been associated with a lower risk of several chronic diseases, but the relationship with PD is unknown.
Objectives
We examined the association of three different plant-based diets with PD incidence in the UK Biobank cohort.
Methods
We conducted a prospective study among 126,283 participants from the UK Biobank cohort. Three plant-based diet indices (overall plant-based diet index, PDI; healthful plant-based diet index, hPDI; and unhealthful plant-based diet index, uPDI) were derived from 24-hour dietary recalls based on 17 food groups. Multivariable Cox regression models were used to estimate the risk of PD across quartiles of the PDIs and for each of the food groups that constituted the score. Further analyses were carried out to assess potential heterogeneity in associations between hPDI and PD across strata of some hypothesized effect modifiers.
Results
During 11.8 years of follow-up (1,490,139 person-years), 577 cases of PD incidence were reported. After multivariable adjustment, participants in the highest hPDI and overall PDI quartile had lower risk of PD (22% and 18%, respectively), whereas a higher uPDI was associated with a 38% higher PD risk. In food-based analyses, higher intakes of vegetables, nuts, and tea were associated with a lower risk of PD (28%, 31% and 25%, respectively). Stratifying by Polygenic Risk Score (PRS), results were significant only for those with a lower PRS for PD.
Conclusions
Following a healthful plant-based diet and in particular the inclusion of readily achievable intakes of vegetables, nuts and tea in the habitual diet are associated with a lower risk of PD.
Original language | English |
---|---|
Pages (from-to) | 1994-2004 |
Journal | Movement Disorders |
Volume | 38 |
Issue number | 11 |
Early online date | 21 Aug 2023 |
DOIs | |
Publication status | Published - Nov 2023 |
Keywords
- neurology
- neurology (clinical)
Fingerprint
Dive into the research topics of 'Plant-based dietary patterns and Parkinson's disease: a prospective analysis of the UK Biobank'. Together they form a unique fingerprint.Student theses
-
Plant-based diets and chronic disease risk: findings from a population-based study
Thompson, A. S. (Author), Kuhn, T. (Supervisor) & Cassidy, A. (Supervisor), Dec 2024Student thesis: Doctoral Thesis › Doctor of Philosophy
File