Plant metabolite 5-pentadecyl resorcinol is produced by the Amazonian fungus Penicillium sclerotiorum LM 5679

L A Oliveira, M M Macedo, J L S Rodrigues, E S Lima, P G Hamill, T D Dallas, M P Lima, E S Souza, J. E. Hallsworth, J V B Souza

Research output: Contribution to journalArticlepeer-review

3 Downloads (Pure)

Abstract

Since the classic studies of Alexander Flemming, Penicillium strains have been known as a rich source of antimicrobial substances. Recent studies have identified novel metabolites produced by Penicillium sclerotiorum that have antibacterial, antifouling and pharmaceutical activities. Here, we report the isolation of a P. sclerotiorum (LM 5679) from Amazonian soil and carry out a culture-based study to determine whether it can produce any novel secondary metabolite(s) that are not thus-far reported for this genus. Using a submerged culture system, secondary metabolites were recovered by solvent extract followed by thin-layer chromatography, nuclear magnetic resonance, and mass spectroscopy. One novel secondary metabolite was isolated from P. sclerotiorum (LM 5679); the phenolic compound 5-pentadecyl resorcinol widely known as an antifungal, that is produced by diverse plant species. This metabolite was not reported previously in any Penicillium species and was only found once before in fungi (that time, in a Fusarium). Here, we discuss the known activities of 5-pentadecyl resorcinol in the context of its mode-of-action as a hydrophobic (chaotropicity-mediated) stressor.
Original languageEnglish
Article numbere241863
Number of pages9
JournalBrazilian journal of biology = Revista brasleira de biologia
Volume82
Early online date11 Jun 2021
DOIs
Publication statusEarly online date - 11 Jun 2021

Fingerprint

Dive into the research topics of 'Plant metabolite 5-pentadecyl resorcinol is produced by the Amazonian fungus Penicillium sclerotiorum LM 5679'. Together they form a unique fingerprint.

Cite this