Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 369-372 |
| Number of pages | 4 |
| Journal | Journal of Alzheimer's disease : JAD |
| Volume | 45 |
| Issue number | 2 |
| Early online date | 07 Jan 2015 |
| DOIs | |
| Publication status | Published - 2015 |
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Plasma Complement factor H in Alzheimer's Disease. / Williams, Michael A.; Haughton, David; Stevenson, Michael; Craig, David; Passmore, A. Peter; Silvestri, Giuliana.
In: Journal of Alzheimer's disease : JAD, Vol. 45, No. 2, 2015, p. 369-372.Research output: Contribution to journal › Article
TY - JOUR
T1 - Plasma Complement factor H in Alzheimer's Disease.
AU - Williams, Michael A.
AU - Haughton, David
AU - Stevenson, Michael
AU - Craig, David
AU - Passmore, A. Peter
AU - Silvestri, Giuliana
PY - 2015
Y1 - 2015
N2 - Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results. This study compared plasma CFH levels in 317 AD cases with 254 controls using an immunodiffusion assay. The sample had an 80% power to detect a difference of 23 mg/L between cases and controls, but no difference was evident. Plasma CFH may not be a suitable biomarker for AD.
AB - Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results. This study compared plasma CFH levels in 317 AD cases with 254 controls using an immunodiffusion assay. The sample had an 80% power to detect a difference of 23 mg/L between cases and controls, but no difference was evident. Plasma CFH may not be a suitable biomarker for AD.
U2 - 10.3233/JAD-142742
DO - 10.3233/JAD-142742
M3 - Article
VL - 45
SP - 369
EP - 372
JO - Journal of Alzheimer's disease : JAD
JF - Journal of Alzheimer's disease : JAD
SN - 1387-2877
IS - 2
ER -