Plasma Complement factor H in Alzheimer's Disease.

Michael A. Williams; David Haughton; Michael Stevenson; David Craig; A. Peter Passmore; Giuliana Silvestri

doi:10.3233/JAD-142742

Plasma Complement factor H in Alzheimer's Disease.

Michael A. Williams, David Haughton, Michael Stevenson, David Craig, A. Peter Passmore, Giuliana Silvestri

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results. This study compared plasma CFH levels in 317 AD cases with 254 controls using an immunodiffusion assay. The sample had an 80% power to detect a difference of 23 mg/L between cases and controls, but no difference was evident. Plasma CFH may not be a suitable biomarker for AD.

Original language	English
Pages (from-to)	369-372
Number of pages	4
Journal	Journal of Alzheimer's disease : JAD
Volume	45
Issue number	2
Early online date	07 Jan 2015
DOIs	https://doi.org/10.3233/JAD-142742
Publication status	Published - 2015

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title = "Plasma Complement factor H in Alzheimer's Disease.",

abstract = "Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results. This study compared plasma CFH levels in 317 AD cases with 254 controls using an immunodiffusion assay. The sample had an 80% power to detect a difference of 23 mg/L between cases and controls, but no difference was evident. Plasma CFH may not be a suitable biomarker for AD.",

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AU - Stevenson, Michael

AU - Craig, David

AU - Passmore, A. Peter

AU - Silvestri, Giuliana

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AB - Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results. This study compared plasma CFH levels in 317 AD cases with 254 controls using an immunodiffusion assay. The sample had an 80% power to detect a difference of 23 mg/L between cases and controls, but no difference was evident. Plasma CFH may not be a suitable biomarker for AD.

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DO - 10.3233/JAD-142742

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