Plasma concentrations of glucagon-like peptide-2 in adult patients with treated and untreated coeliac disease

Grant R Caddy, Joy E S Ardill, Davina Fillmore, Carolyn M Caldwell, Bronac M McKibben, Keith R Gardiner, Peter R G Watson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Coeliac disease is a common chronic inflammatory enteropathy characterized by villous atrophy and crypt hyperplasia in the small intestine. The mechanism of the intestinal damage in coeliac disease remains unclear. Glucagon-like peptide (GLP)-2 is an enterotrophic peptide that causes crypt hyperplasia and intestinal cell proliferation. We postulate that GLP-2 may be involved in the mucosal changes found in coeliac disease.
Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Volume18
Issue number2
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Gastroenterology

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