Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk

Eunjung Lee*, Daniel O. Stram, Weronica E. Ek, Lynn E. Onstad, Stuart MacGregor, Puya Gharahkhani, Weimin Ye, Jesper Lagergren, Nicholas J. Shaheen, Liam J. Murray, Laura J. Hardie, Marilie D. Gammon, Wong Ho Chow, Harvey A. Risch, Douglas A. Corley, David M. Levine, David C. Whiteman, Leslie Bernstein, Nigel C. Bird, Thomas L. VaughanAnna H. Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus. 

Methods: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn. 

Results: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed. 

Conclusions: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus. 

Impact: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus.

Original languageEnglish
Pages (from-to)1801-1803
Number of pages3
JournalCancer Epidemiology Biomarkers & Prevention
Issue number11
Publication statusPublished - 01 Nov 2015

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


Dive into the research topics of 'Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk'. Together they form a unique fingerprint.

Cite this