Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk

Eunjung Lee; Daniel O. Stram; Weronica E. Ek; Lynn E. Onstad; Stuart MacGregor; Puya Gharahkhani; Weimin Ye; Jesper Lagergren; Nicholas J. Shaheen; Liam J. Murray; Laura J. Hardie; Marilie D. Gammon; Wong Ho Chow; Harvey A. Risch; Douglas A. Corley; David M. Levine; David C. Whiteman; Leslie Bernstein; Nigel C. Bird; Thomas L. Vaughan; Anna H. Wu

doi:10.1158/1055-9965.EPI-15-0596

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk

Eunjung Lee^*, Daniel O. Stram, Weronica E. Ek, Lynn E. Onstad, Stuart MacGregor, Puya Gharahkhani, Weimin Ye, Jesper Lagergren, Nicholas J. Shaheen, Liam J. Murray, Laura J. Hardie, Marilie D. Gammon, Wong Ho Chow, Harvey A. Risch, Douglas A. Corley, David M. Levine, David C. Whiteman, Leslie Bernstein, Nigel C. Bird, Thomas L. VaughanAnna H. Wu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus.

Methods: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn.

Results: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed.

Conclusions: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus.

Impact: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus.

Original language	English
Pages (from-to)	1801-1803
Number of pages	3
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	24
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-15-0596
Publication status	Published - 01 Nov 2015

ASJC Scopus subject areas

Epidemiology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1158/1055-9965.EPI-15-0596

Cite this

Lee, E., Stram, D. O., Ek, W. E., Onstad, L. E., MacGregor, S., Gharahkhani, P., Ye, W., Lagergren, J., Shaheen, N. J., Murray, L. J., Hardie, L. J., Gammon, M. D., Chow, W. H., Risch, H. A., Corley, D. A., Levine, D. M., Whiteman, D. C., Bernstein, L., Bird, N. C., ... Wu, A. H. (2015). Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk. Cancer Epidemiology Biomarkers & Prevention, 24(11), 1801-1803. https://doi.org/10.1158/1055-9965.EPI-15-0596

@article{729f96be5c6b4e2590bb6f828658b553,

title = "Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk",

abstract = "Background: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus. Methods: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn. Results: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed. Conclusions: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus. Impact: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus.",

author = "Eunjung Lee and Stram, {Daniel O.} and Ek, {Weronica E.} and Onstad, {Lynn E.} and Stuart MacGregor and Puya Gharahkhani and Weimin Ye and Jesper Lagergren and Shaheen, {Nicholas J.} and Murray, {Liam J.} and Hardie, {Laura J.} and Gammon, {Marilie D.} and Chow, {Wong Ho} and Risch, {Harvey A.} and Corley, {Douglas A.} and Levine, {David M.} and Whiteman, {David C.} and Leslie Bernstein and Bird, {Nigel C.} and Vaughan, {Thomas L.} and Wu, {Anna H.}",

year = "2015",

month = nov,

day = "1",

doi = "10.1158/1055-9965.EPI-15-0596",

language = "English",

volume = "24",

pages = "1801--1803",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "11",

}

Lee, E, Stram, DO, Ek, WE, Onstad, LE, MacGregor, S, Gharahkhani, P, Ye, W, Lagergren, J, Shaheen, NJ, Murray, LJ, Hardie, LJ, Gammon, MD, Chow, WH, Risch, HA, Corley, DA, Levine, DM, Whiteman, DC, Bernstein, L, Bird, NC, Vaughan, TL & Wu, AH 2015, 'Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk', Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 11, pp. 1801-1803. https://doi.org/10.1158/1055-9965.EPI-15-0596

TY - JOUR

T1 - Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk

AU - Lee, Eunjung

AU - Stram, Daniel O.

AU - Ek, Weronica E.

AU - Onstad, Lynn E.

AU - MacGregor, Stuart

AU - Gharahkhani, Puya

AU - Ye, Weimin

AU - Lagergren, Jesper

AU - Shaheen, Nicholas J.

AU - Murray, Liam J.

AU - Hardie, Laura J.

AU - Gammon, Marilie D.

AU - Chow, Wong Ho

AU - Risch, Harvey A.

AU - Corley, Douglas A.

AU - Levine, David M.

AU - Whiteman, David C.

AU - Bernstein, Leslie

AU - Bird, Nigel C.

AU - Vaughan, Thomas L.

AU - Wu, Anna H.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus. Methods: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn. Results: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed. Conclusions: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus. Impact: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus.

AB - Background: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus. Methods: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn. Results: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed. Conclusions: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus. Impact: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus.

UR - http://www.scopus.com/inward/record.url?scp=84946556634&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-15-0596

DO - 10.1158/1055-9965.EPI-15-0596

M3 - Article

AN - SCOPUS:84946556634

SN - 1055-9965

VL - 24

SP - 1801

EP - 1803

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 11

ER -

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this